期刊论文

Li, Lanfang;Chen, Linxi

英文

DNA AND CELL BIOLOGY

1044-5498

2016

35

12

766-775

10.1089/dna.2016.3391

National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81270420, 81470434, 81503074, 81670265]; Zhengxiang Scholar Program of University of South China [2014-004]; Hunan Provincial Science and Technology Project [2015RS4040]; Administration of Traditional Chinese Medicine of Hunan Province [201578]; Health and Family planning commission of Hunan Province [B2015-48]

本校为第一且通讯机构

Apelin is the endogenous ligand of the G protein-coupled receptor, APJ. Recently, researches indicate that the apelin/APJ system involves in myocardial ischemia-reperfusion injury (MIRI), which is a common pathophysiological process in patients with heart diseases and therapies. The reperfusion induces the expression of apelin and APJ receptor, which play an important role in cardioprotection of MIRI. The apelin/APJ system alleviates MIRI mainly by decreasing mitochondrial reactive oxygen species and delaying the opening of mitochondrial permea...