MicroRNA-134 Promotes the Development of Atherosclerosis Via the ANGPTL4/LPL Pathway in Apolipoprotein E Knockout Mice

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成果类型：

期刊论文

作者：

Ye, Qiong;Tian, Guo-Ping;Cheng, Hai-Peng;Zhang, Xin;Ou, Xiang;...

通讯作者：

Tang, Chao-Ke

作者机构：

[Zhang, Xin; Gong, Duo; Cheng, Hai-Peng; Ye, Qiong; Xia, Xiao-Dan; Zhang, Min; Tang, Chao-Ke; Zhao, Zhen-Wang; Yu, Xiao-Hua; Li, Liang; Xie, Wei; Huang, Chong; Chen, Ling-Yan] Univ South China, Hunan Prov Cooperat Innovat Ctr Mol Target New Dr, Med Res Ctr, Inst Cardiovasc Res,Key Lab Atherosclerol Hunan P, Hengyang, Hunan, Peoples R China.

[Tan, Ru-Qi; Ye, Qiong; Tian, Guo-Ping; Yang, Feng-Yun; Pan, Yan-Jun] Univ South China, Affiliated Hosp 2, Dept Cardiovasc Med, Hengyang, Hunan, Peoples R China.

[Ou, Xiang] First Hosp Changsha, Dept Endocrinol, Changsha, Hunan, Peoples R China.

[Zhang, Jie] Univ South China, Affiliated Hosp 2, Dept Spinal Surg, Hengyang, Hunan, Peoples R China.

[Zheng, Xi-Long] Univ Calgary, Hlth Sci Ctr, Libin Cardiovasc Inst Alberta, Cumming Sch Med,Dept Biochem & Mol Biol, 3330 Hosp Dr NW, Calgary, AB, Canada.

通讯机构：

[Tang, Chao-Ke] U

Univ South China, Inst Cardiovasc Res, Hengyang 421001, Hunan, Peoples R China.

语种：

英文

关键词：

MiR-134;ANGPTL4;LPL;Atherosclerosis

期刊：

Journal of Atherosclerosis and Thrombosis

ISSN：

1340-3478

年：

2018

卷：

期：

页码：

244-253

DOI：

10.5551/jat.40212

基金类别：

National Natural Sciences Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81570408, 81370377]; Natural Science Foundation of Hunan ProvinceNatural Science Foundation of Hunan Province [2015JJ2120, 2017JJ2286]; construct program of the key discipline in Hunan province (Basic Medicine Sciences in University of South China, Xiangjiaofa) [[2011]76]; Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study [0223-0002-0002000-41, 0223-0002-0002000-42]; Science and Technology Plan Project of Changsha City [KQ1602028]

机构署名：

本校为第一且通讯机构

院系归属：

医学院

药学与生物科学学院

摘要：

Aims: Atherosclerosis is the most common cause of cardiovascular disease, such as myocardial infarction and stroke. Previous study revealed that microRNA (miR)-134 promotes lipid accumulation and proinflammatory cytokine secretion through angiopoietin-like 4 (ANGPTL4)/lipid lipoprotein (LPL) signaling in THP-1 macrophages. Methods: ApoE KO male mice on a C57BL/6 background were fed a high-fat/high-cholesterol Western diet, from 8 to 16 weeks of age. Mice were divided into four groups, and received a tail vein injection of miR-134 agomir, miR-134 antagomir, or one of the corresponding controls,...

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MicroRNA-134 Promotes the Development of Atherosclerosis Via the ANGPTL4/LPL Pathway in Apolipoprotein E Knockout Mice

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