MicroRNA-134 promotes the development of atherosclerosis via the angptl4/lpl pathway in apolipoprotein e knockout mice

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成果类型：

期刊论文

作者：

Ye, Qiong;Tian, Guo-Ping;Cheng, Hai-Peng;Zhang, Xin;Ou, Xiang;...

通讯作者：

Tang, Chao-Ke

作者机构：

[Zhang, Xin; Gong, Duo; Cheng, Hai-Peng; Ye, Qiong; Xia, Xiao-Dan; Zhang, Min; Tang, Chao-Ke; Zhao, Zhen-Wang; Yu, Xiao-Hua; Li, Liang; Xie, Wei; Huang, Chong; Chen, Ling-Yan] Univ South China, Hunan Prov Cooperat Innovat Ctr Mol Target New Dr, Med Res Ctr, Inst Cardiovasc Res,Key Lab Atherosclerol Hunan P, Hengyang, Hunan, Peoples R China.

[Tan, Ru-Qi; Ye, Qiong; Tian, Guo-Ping; Yang, Feng-Yun; Pan, Yan-Jun] Univ South China, Affiliated Hosp 2, Dept Cardiovasc Med, Hengyang, Hunan, Peoples R China.

[Ou, Xiang] First Hosp Changsha, Dept Endocrinol, Changsha, Hunan, Peoples R China.

[Zhang, Jie] Univ South China, Affiliated Hosp 2, Dept Spinal Surg, Hengyang, Hunan, Peoples R China.

[Zheng, Xi-Long] Univ Calgary, Hlth Sci Ctr, Libin Cardiovasc Inst Alberta, Cumming Sch Med,Dept Biochem & Mol Biol, 3330 Hosp Dr NW, Calgary, AB, Canada.

通讯机构：

[Tang, Chao-Ke] U

Univ South China, Inst Cardiovasc Res, Hengyang 421001, Hunan, Peoples R China.

语种：

英文

关键词：

angiopoietin related protein 4;apolipoprotein E;high density lipoprotein cholesterol;interleukin 1beta;interleukin 6;low density lipoprotein cholesterol;microRNA;microRNA 134;monocyte chemotactic protein 1;tumor necrosis factor;unclassified drug;angiopoietin related protein 4;Angptl4 protein, mouse;cholesterol;cytokine;lipid;lipoprotein lipase;microRNA;MIRN132 microRNA, mouse;analysis of variance;animal experiment;animal model;animal tissue;Article;atherosclerosis;body weight;chromatin immunoprecipitation;connective tissue;controlled study;cytokine production;gene overexpression;high performance liquid chromatography;incubation temperature;inflammation;lipid diet;lipid storage;macrophage;male;microscopy;mortality;mouse;nonhuman;observational study;peritoneum macrophage;protein expression;real time polymerase chain reaction;receptor upregulation;reverse transcription polymerase chain reaction;signal transduction;Western blotting;animal;apolipoprotein E knockout mouse;atherosclerosis;blood;C57BL mouse;chemistry;foam cell;genetics;metabolism;Angiopoietin-like 4 Protein;Animals;Atherosclerosis;Cholesterol;Cytokines;Foam Cells;Inflammation;Lipids;Lipoprotein Lipase;Macrophages;Male;Mice;Mice, Inbred C57BL;Mice, Knockout, ApoE;MicroRNAs

期刊：

Journal of Atherosclerosis and Thrombosis

ISSN：

1340-3478

年：

2018

卷：

期：

页码：

244-253

DOI：

10.5551/jat.40212

基金类别：

The authors gratefully acknowledge financial support from the National Natural Sciences Foundation of China (81570408, and 81370377), the Natural Science Foundation of Hunan Province (2015JJ2120), the construct program of the key discipline in Hunan province (Basic Medicine Sciences in University of South China, Xiangjiaofa NO. [2011]76), Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study (0223-0002-0002000-41, 0223-0002-0002000-42) and Science and Technology Plan Project of Changsha City (KQ1602028) and the Natural Science Foundation of Hunan Province (2017JJ2286) The authors gratefully acknowledge financial support from the National Natural Sciences Foundation of China (81570408, and 81370377), the Natural Science Foundation of Hunan Province (2015JJ2120), the construct program of the key discipline in Hunan province (Basic Medicine Sciences in University of South China, Xiangjiaofa NO. [2011]76), Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study (0223-0002-0002000-41, 0223-0002-0002000-42) and Science and Technology Plan Project of Changsha City (KQl 602028) and the Natural Science Foundation of Hunan Province (2017JJ2286).

机构署名：

本校为第一且通讯机构

院系归属：

医学院

药学与生物科学学院

摘要：

Atherosclerosis is the most common cause of cardiovascular disease, such as myocardial infarction and stroke. Previous study revealed that microRNA (miR)-134 promotes lipid accumulation and proinflammatory cytokine secretion through angiopoietin-like 4 (ANGPTL4)/lipid lipoprotein (LPL) signaling in THP-1 macrophages. Methods: ApoE KO male mice on a C57BL/6 background were fed a high-fat/high-cholesterol Western diet, from 8 to 16 weeks of age. Mice were divided into four groups, and received a tail vein injection of miR-134 agomir, miR-134 anta...

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MicroRNA-134 promotes the development of atherosclerosis via the angptl4/lpl pathway in apolipoprotein e knockout mice

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