Growth inhibition and induction of G1 phase cell cycle arrest in neuroblastoma SH-SY5Y cell by tri-ortho-cresyl phosphate

首页 > 成果 > 详情

认领

导出

下载 Link by DOI

反馈

作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Long, Ding-Xin;Wu, Yi-Jun*

通讯作者：

Wu, Yi-Jun

作者机构：

[Wu, Yi-Jun; Long, Ding-Xin] Chinese Acad Sci, Inst Zool, Mol Toxicol Lab, State Key Lab Integrated Management Pest Insects, Beijing 100101, Peoples R China.

[Long, Ding-Xin] Chinese Acad Sci, Grad Univ, Beijing 100039, Peoples R China.

[Long, Ding-Xin] Univ S China, Sch Publ Hlth, Hengyang 421001, Peoples R China.

[Wu, Yi-Jun] Chinese Acad Sci, Inst Zool, Mol Toxicol Lab, State Key Lab Integrated Management Pest Insects, Datunlu Rd, Beijing 100101, Peoples R China.

通讯机构：

[Wu, Yi-Jun] C

Chinese Acad Sci, Inst Zool, Mol Toxicol Lab, State Key Lab Integrated Management Pest Insects, Datunlu Rd, Beijing 100101, Peoples R China.

语种：

英文

关键词：

Tri-ortho-cresyl phosphate;Cell proliferation;Cell cycle;Neurotoxicity;SH-SY5Y cell

期刊：

Toxicology Letters

ISSN：

0378-4274

年：

2008

卷：

181

期：

页码：

47-52

DOI：

10.1016/j.toxlet.2008.06.871

基金类别：

National 863 Program [2006AA06Z423]; National Key Technologies RD Program [2006BAK02A02]

机构署名：

本校为其他机构

院系归属：

公共卫生学院

摘要：

It has been known that tri-ortho-cresyl phosphate (TOCP) can induce delayed neurotoxicity in humans and sensitive animal species: however, it also has influence on the developing central nervous system or differentiating neuronal cells. In this study, the effects of TOCP on cell proliferation and cell cycle regulation and the mechanisms that contribute to this effect were investigated by using human neuroblastoma SH-SY5Y cell line. Treatment of the cells with TOCP suppressed cell proliferation and reduced cell viability in a dose- and time-dependent manner. Analysis of cell cycle profile indic...

反馈

产权有误：本人成果被他人认领

数据有误：数据基本信息有误

归属有误：成果的院系归属、机构署名归属有误

其他原因：

验证码：

看不清楚，换一个

确定

取消

成果认领

标题：

用户	作者	通讯作者	--
	请选择	请选择	--

确定

取消

Growth inhibition and induction of G1 phase cell cycle arrest in neuroblastoma SH-SY5Y cell by tri-ortho-cresyl phosphate

反馈

成果认领

提示

该栏目需要登录且有访问权限才可以访问