Silencing TAB182 inhibits cell EMT, migration and invasion by downregulating EGFR in A549 NSCLC cells

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成果类型：

期刊论文

作者：

Wang, Shaozheng;Guo, Hejiang;Jia, Jin;Zhang, Wen;Gao, Shanshan;...

通讯作者：

Huan He<&wdkj&>Pingkun Zhou

作者机构：

[Wang, Shaozheng; Guan, Hua; Guo, Hejiang; Zhou, Pingkun; Zhang, Wen; Gao, Shanshan; Jia, Jin; He, Huan] Beijing Inst Radiat Med, Dept Radiat Toxicol & Oncol, Beijing Key Lab Radiobiol, Beijing 100850, Peoples R China.

[Zhou, Pingkun; Zhang, Wen; Jia, Jin] Univ South China, Sch Med, Hengyang 421001, Peoples R China.

[He, Huan] Jilin Univ, Sch Publ Hlth, NHC Key Lab Radiobiol, Changchun 130021, Peoples R China.

通讯机构：

[Huan He; Pingkun Zhou] D

Department of Radiation Toxicology and Oncology, Beijing Key Laboratory for Radiobiology, Beijing Institute of Radiation Medicine, Beijing, China<&wdkj&>NHC Key Laboratory of Radiobiology, School of Public Health, Jilin University, Changchun, China<&wdkj&>Department of Radiation Toxicology and Oncology, Beijing Key Laboratory for Radiobiology, Beijing Institute of Radiation Medicine, Beijing, China<&wdkj&>School of Medicine, University of South China, Hengyang, China

语种：

英文

关键词：

TAB182;EGFR;Cell invasion;Cell migration;EMT;Lung cancer cells

期刊：

Molecular Biology Reports

ISSN：

0301-4851

年：

2023

卷：

期：

页码：

3073-3083

DOI：

10.1007/s11033-022-08176-5

基金类别：

This study was supported by the National Natural Science Foundation of China, 31870847 and 32171238 to Pingkun Zhou, Postdoctoral Research Foundation of China, 2021M693965 to Huan He

机构署名：

本校为其他机构

院系归属：

医学院

摘要：

BACKGROUND: TAB182 is overexpressed in cancerous tissues and correlated with poor overall survival in lung cancer patients. Mechanistically, TAB182 participates in DNA damage repair and endows tumour cells with radio- and chemoresistance. However, its role in non-small cell lung cancer (NSCLC) remains unclear. METHODS AND RESULTS: Cells with stable TAB182 knockdown (KD) were generated using A549 NSCLC cells, and we demonstrated that depleting TAB182 inhibits cell EMT, proliferation, colony formation, migration and invasion. Analysis of the TCGA database showed a positive correlation between TA...

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Silencing TAB182 inhibits cell EMT, migration and invasion by downregulating EGFR in A549 NSCLC cells

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