期刊论文

Zhang, P.

中文

中国组织工程研究

2095-4344

2007

11

21

4112-4115

10.3321/j.issn:1673-8225.2007.21.028

湖南省衡阳市科学技术局科研基金资助（2005KS01011）

本校为第一且通讯机构

目的:观察黄芪注射液对急性肺损伤时肺组织白细胞介素1β和肿瘤坏死因子α表达的影响,分析黄芪在急性肺损伤中的治疗机制.方法:实验于2005-11/2006-04在南华大学动物实验中心完成.清洁级健康SD雄性大鼠24只,以随机数字表法分3组,即对照组、模型组和黄芪组,各8只.对照组从尾静脉注入1 mL生理盐水;模型组和黄芪组以内毒素5 mg/kg溶解于1 mL生理盐水,从尾静脉注入,制造急性肺损伤模型;45 min后,黄芪组予黄芪注射液(每支10 mL含20 g生药,成都地奥九泓制药厂)0.5 g/kg,加生理盐水稀释成1 mL,并从尾静脉注入.免疫组化法检测各组肺组织白细胞介素1β和肿瘤坏死因子α的表达情况.并做肺组织大体观察和20...

Aim: To observe the effects of astragalus mongholicus injection on the expressions of interleukin 1β (IL- 1β) and tumor necrosis factor α (TNF-α) in the lung tissues of rats with acute lung injury, and explore the mechanism of astragalus mongholicus in treating acute lung injury. Methods: The experiment was conducted in the animal experiment center of Nanhua University Between November 2005 and April 2006. Twenty-four clean grade healthy male SD rats were randomly divided into three groups: normal group, model group and astragatus mongholic...