期刊论文

Zhang, P.

中文

中国组织工程研究

2095-4344

2007

11

21

4108-4111

10.3321/j.issn:1673-8225.2007.21.027

衡阳市科技局研究项目基金资助项目（06kj13）

本校为第一且通讯机构

目的：观察阻断肾素-血管紧张素-醛固酮系统不同环节对实验性肺纤维化大鼠肺组织肿瘤坏死因子α的影响。方法：实验于2005-08/2006-08在南华大学附属第一医院临床研究所及南华大学医学院组胚、生理实验室完成。取6周龄SD大鼠50只，随机分为正常对照组、模型组、卡托普利组、螺内酯组和氯沙坦组，每组10只。正常对照组气管内注入生理盐水，其他40只SD大鼠气管内注入博莱霉素5mg/kg复制肺纤维化模型。次日胃管内灌注血管紧张素转换酶抑制剂卡托普利60mg/kg（卡托普利组）、血管紧张素Ⅱ的Ⅰ型受体阻断剂氯沙坦10mg/kg（氯沙坦组）、醛固酮受体拮抗剂螺内酯100mg/kg（螺内酯组）、等量生理盐水（模...

Aim: To observe the effects on the expression of tumor necrosis factor-α (TNF-α) in pulmonary fibrosis in rats after the blokage of renin-angiotensin-aldosterone system at different levels. Methods: The experiment was carried out in the Clinical Institute of the First Affiliated Hospital of Nanhua University and the Laboratory of Histoembryology and Physiology in Nanhua University Medical College from August 2005 to August 2006. Fifty SD rats aged 6 weeks were randomized into five groups, with 10 rats in each. In the normal control group, the...