期刊论文

Mo, L.-J.

中文

中国组织工程研究

2095-4344

2006

10

25

150-152

10.3321/j.issn:1673-8225.2006.25.061

本校为第一且通讯机构

目的:骨形态发生蛋白12属于转化生长因子β超家族成员,能诱导间充质干细胞定向分化为成腱细胞.重组人骨形态发生蛋白12不但能使腱纤维原细胞的增殖,还能使Ⅰ型和Ⅲ型原胶原高表达,有助于肌腱的修复和愈合.回顾骨形态发生蛋白12的发展及其研究成果,并对其综述.资料来源:应用计算机检索NCBI Entrez Pubmed和CNKI 1965-01/2004-12骨形态发生蛋白12的相关文献,检索词:骨形态发生蛋白12(bone morphogenetic protein-12),损伤(repairing).资料选择:对资料进行初审,纳入标准:①有关骨形态发生蛋白12生物学效应.②有关骨形态发生蛋白12与其家族成员比较研究.排除标准:重复研究.资料提炼:共收集42篇相关文...

Objective: Bone morphogenetic protein-12, as one member of the transforming growth factor-β superfamily, can induce the mesenchymal stem cells differentiating into bonding cells. Recombinant human bone morphogenetic protein-12 can increase proliferation of tendon fibroblasts and the gene expressions of procollagen type I and type III, which is helpful to the repairing and healing of tendon tissues. In this paper, we review and summarize the development and achievement of the bone morphogenetic protein-12. Data sources: The computer-based onlin...