期刊论文

Tang, C.-K.

中文

中国组织工程研究

2095-4344

2006

10

48

77-79

10.3321/j.issn:1673-8225.2006.48.028

国家自然科学基金资助项目（30470720） 中国博士后科学基金资助项目（2005037157）

本校为第一且通讯机构

目的:用贵州小香猪建立动脉粥样硬化动物模型,观察小型猪动脉粥样硬化发生发展与血浆C-反应蛋白水平的关系.方法:实验于2003-02/2004-03在南华大学心血管病研究所实验室进行.选择10只贵州小香猪单纯随机分为两组(n=5):①高脂高胆固醇组:喂饲高脂高胆固醇饲料2个月后麻醉状态下切开右侧颈总动脉放置6F动脉球囊导管,压力600～800kPa×180 s,重复2次,然后在200～400kPa压力下从远端向近端拖拉球囊导管,并重复3次,术后饲以高脂高胆固醇饲料.②正常对照组:普通饲料喂养2个月后麻醉状态下分离右侧颈总动脉,但不进行血管内膜损伤.实验进行12个月,每2个月检测1次血浆总胆固醇、三酰甘油和高密度脂蛋白胆...

Aim: To establish animal models of atherosclerosis in minipigs and investigate the change of plasma C-reactive protein level in atherosclerotic minipigs. Methods: The experiment was performed in the Laboratory of Cardiovascular Disease of Nanhua University from Feburary 2003 to March 2004. Ten minipigs were selected and randomly divided into 2 groups with 5 minipigs in each group: 1 High fat and high cholesterol (HFHC) group: rats were fed with HFHC diet and cut open the left common carotid artery (CCA) under anesthetized after 2 months to plac...