Neopterin negatively regulates expression of ABCA1 and ABCG1 by the LXR alpha signaling pathway in THP-1 macrophage-derived foam cells

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成果类型：

期刊论文

作者：

Yan, Jin-quan;Tan, Chun-zhi*;Wu, Jin-hua;Zhang, Dong-cui;Chen, Ji-ling;...

通讯作者：

Tan, Chun-zhi

作者机构：

[Yan, Jin-quan] Shaoyang Med Coll, Affiliated Hosp, Shaoyang 422000, Hunan, Peoples R China.

[Liu, Qin; Dai, Hao; Tan, Chun-zhi; Zeng, Bin-yuan; Liu, Wei; Jiang, Yu-ping; Nie, Jin] First Peoples Hosp Shaoyang City, Shaoyang 422000, Hunan, Peoples R China.

[Tan, Chun-zhi] Univ South China, Inst Cardiovasc Res, Key Lab Atherosclerol Hunan Prov, Life Sci Res Ctr, Hengyang 421001, Hunan, Peoples R China.

[Wu, Jin-hua] Nanhua Univ, Affiliated Hosp 2, Hengyang 421001, Hunan, Peoples R China.

[Zhang, Dong-cui] Hunan Prov Geriatr Hosp, Changsha 410000, Hunan, Peoples R China.

通讯机构：

[Tan, Chun-zhi] F

First Peoples Hosp Shaoyang City, Shaoyang 422000, Hunan, Peoples R China.

语种：

英文

关键词：

Neopterin;ABCA1;Cholesterol efflux;LXR alpha;Atherosclerosis

期刊：

Molecular and Cellular Biochemistry

ISSN：

0300-8177

年：

2013

卷：

379

期：

1-2

页码：

123-131

DOI：

10.1007/s11010-013-1634-6

机构署名：

本校为其他机构

院系归属：

国防科学技术学院

医学院

药学与生物科学学院

摘要：

To investigate the effects of neopterin on ABCA1 expression and cholesterol efflux in human THP-1 macrophage-derived foam cells, and to explore the role of the liver X receptor alpha (LXRα) involved. In the present study, THP-1 cells were pre-incubated with ox-LDL to become foam cells. The protein and mRNA expression were examined by Western blot assays and real-time quantitative PCR, respectively. Liquid scintillation counting and high performance liquid chromatography assays were used to test cellular cholesterol efflux and cholesterol conte...

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Neopterin negatively regulates expression of ABCA1 and ABCG1 by the LXR alpha signaling pathway in THP-1 macrophage-derived foam cells

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