期刊论文

Qin, Xuping

英文

Clinica Chimica Acta

0009-8981

2021

513

25-33

10.1016/j.cca.2020.11.020

Atherosclerosis is a complex progressive pathophysiological alteration normally associated with disorders of lipid metabolism and inflammatory responses, including hypertension, diabetes, hypercholesterolemia, and endothelial injury [96], [97]. Multiple studies have revealed that autophagy activates a protective programme in atherosclerosis, and exacerbated autophagosome formation for degrading cellular components may play an ameliorating role in the pathophysiological condition of

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Caveolin-1 is considered an important pathophysiological factor in atherosclerosis development. Previous studies indicate that caveolin-1 exhibits a pathogenic capacity in atherosclerosis via the regulation of membrane trafficking, cholesterol metabolism and cellular signal transduction. Accumulating evidence shows that autophagy activation influences the progression and development of atherosclerosis in multiple ways, including cholesterol metabolism, inflammatory responses and lipid transcytosis. However, how caveolin-1 is involved in autophagy activation in atherosclerosis remains unclear, ...