期刊论文

中文

菌物学报

1672-6472

2023

42

2

484-494

10.13346/j.mycosystema.220196

This work was supported by the National Natural Science Foundation of China (31500014) and the Science and Technology Program of Hengyang (2016KS26). *Corresponding author. E-mail: haohao200701@126.com Received: 2022-05-22; Accepted: 2022-07-12

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奥默儿玉氏酵母Kodamaea ohmeri已经成为一种重要的新兴人类酵母病原体。本文利用形态学和ITS序列分析鉴定分离自患者腹水的临床菌株3873为K.ohmeri。5-氟胞嘧啶、两性霉素B、氟康唑、伊曲康唑和伏立康对...展开更多 奥默儿玉氏酵母Kodamaea ohmeri已经成为一种重要的新兴人类酵母病原体。本文利用形态学和ITS序列分析鉴定分离自患者腹水的临床菌株3873为K.ohmeri。5-氟胞嘧啶、两性霉素B、氟康唑、伊曲康唑和伏立康对菌株3873的MIC值分别为≤4、≤0.5、≤4、≤0.125和≤0.6 mg/L。菌株3873在血清诱导下发育出假菌丝,无法形成真菌丝,且在微需氧条件下侵入能力强;最适生长温度和pH分别为37℃和7....

Kodamaea ohmeri has emerged as an important human yeast pathogen. A clinical strain 3873 isolated from ascites of a patient was identified as K. ohmeri based on morphology and ITS sequence analysis. The MIC values of 5-flucytosine, amphotericin B, fluconazole, itraconazole and voriconazole of the strain were ≤4, ≤0.5, ≤4, ≤0.125, and ≤0.6 mg/L, respectively. The strain could produce pseudohyphae, but was unable to form fungal filaments with the induction of serum and had a strong invasive growth ability under microaerophilic conditions. Th...