MiR-597 targeting 14-3-3σ enhances cellular invasion and EMT in nasopharyngeal carcinoma cells

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成果类型：

期刊论文

作者：

Xie, Lisha;Jiang, Tao;Cheng, Ailan;Zhang, Ting;Huang, Pin;...

通讯作者：

Huang, Weiguo;Kuai, Jianke

作者机构：

[Li, Pei; Zhang, Ting; Lei, Fanghong; Xie, Lisha; Cheng, Ailan; Huang, Pin; Jiang, Tao; Huang, Yun; Huang, Weiguo] Univ South China, Canc Res Inst, Hengyang Med Coll, NO28,West Changsheng Rd, Hengyang 421001, Hunan, Peoples R China.

[Wen, Gebo; Cheng, Ailan; Huang, Weiguo] Hunan Prov Key Lab Tumor Cellular & Mol Pathol 20, Hengyang 421001, Hunan, Peoples R China.

[Tang, Xia; Lin, Yunpeng; Gong, Jie] Univ South China, Hengyang Med Coll, Hengyang 421001, Hunan, Peoples R China.

[Kuai, Jianke] Third Hosp Xian, Dept Anesthesiol, NO10,East Sect Fengcheng 3rd Rd, Xian 710018, Shaanxi, Peoples R China.

[Xie, Lisha] Dept Yiyang Cent Hosp, Yiyang 413000, Hunan, Peoples R China.

通讯机构：

[Huang, Weiguo] U

[Kuai, Jianke] T

Univ South China, Canc Res Inst, Hengyang Med Coll, NO28,West Changsheng Rd, Hengyang 421001, Hunan, Peoples R China.

Third Hosp Xian, Dept Anesthesiol, NO10,East Sect Fengcheng 3rd Rd, Xian 710018, Shaanxi, Peoples R China.

语种：

英文

关键词：

NPC;miR-597;EMT;migration;invasion.

期刊：

CURRENT MOLECULAR PHARMACOLOGY

ISSN：

1874-4672

年：

2019

卷：

期：

页码：

105-114

DOI：

10.2174/1874467212666181218113930

基金类别：

The authors declare that they have no competing interests. This project was supported by the Chinese National Science Foundation (No.81172210), China Postdoctoral Science Foundation (No.2012M521528).The peon unfd f o hCi-nese Hunan Provincial Education Department innovation platform (No.15K109), the Hunan Province Science Foundation No(. 0126JJ2102), the oncsructtion program of the key discipline in Hunan Province, China (Basic Medicine Sciences in University of South China).

机构署名：

本校为第一且通讯机构

院系归属：

医学院

摘要：

Background: Alterations in microRNAs (miRNAs) are related to the occurrence of nasopharyngeal carcinoma (NPC) and play an important role in the molecular mechanism of NPC. Our previous studies show low expression of 14-3-3σ (SFN) is related to the metastasis and differentiation of NPC, but the underlying molecular mechanisms remain unclear. Methods: Through bioinformatics analysis, we find miR-597 is the preferred target miRNA of 14-3-3σ. The expression level of 14-3-3σ in NPC cell lines was detected by Western blotting. The expression of mi...

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MiR-597 targeting 14-3-3σ enhances cellular invasion and EMT in nasopharyngeal carcinoma cells

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