NOX4-Derived Reactive Oxygen Species Drive Apelin-13-Induced Vascular Smooth Muscle Cell Proliferation via the ERK Pathway

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Li, Lanfang;Li, Fang;Li, Feng;Mao, Xiaohuan;Yang, Li;...

通讯作者：

Chen, Linxi

作者机构：

[Mao, Xiaohuan; Guo, Yu; Li, Fang; Li, Lanfang; Yang, Li; Huang, Hao; Li, Jian; Chen, Linxi] Univ S China, Inst Pharm & Pharmacol, Learning Key Lab Pharmacoprote, Hengyang 421001, Peoples R China.

[Li, Lanfang; Li, Jian] Beijing Hosp, Key Lab Geriatr, Beijing 100730, Peoples R China.

[Li, Lanfang; Li, Jian] Beijing Inst Geriatr, Minist Hlth, Beijing 100730, Peoples R China.

[Li, Feng] Hunan Coll Tradit Chinese Med, Dept Physiol, Changsha 410007, Hunan, Peoples R China.

通讯机构：

[Chen, Linxi] U

Univ S China, Inst Pharm & Pharmacol, Learning Key Lab Pharmacoprote, Hengyang 421001, Peoples R China.

语种：

英文

关键词：

G protein coupled receptor;Reactive oxygen species;NADPH oxidase;Vascular smooth muscle cell;Proliferation

期刊：

INTERNATIONAL JOURNAL OF PEPTIDE RESEARCH AND THERAPEUTICS

ISSN：

1573-3149

年：

2011

卷：

期：

页码：

307-315

DOI：

10.1007/s10989-011-9269-5

基金类别：

National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [30901577, 81070634]; Hengyang Municipal Bureau of Science and Technology [2009 kJ 14]; Scientific Research Foundation for the Returned Overseas Chinese Scholars, State Education MinistryScientific Research Foundation for the Returned Overseas Chinese Scholars [20091590]

机构署名：

本校为第一且通讯机构

院系归属：

药学与生物科学学院

摘要：

Apelin is the endogenous ligand of the G-protein-coupled receptor, apelin-angiotensin receptor-like 1 (APJ). Vascular smooth muscle cells express both apelin and APJ, which are important regulatory factors in the cardiovascular system. Apelin-13 significantly stimulated vascular smooth muscle cell proliferation. However, little is known about the precise cellular mechanisms responsible for vascular smooth muscle cell proliferation induced by apelin-13. Here, we present novel data that indicate the key role of NADPH oxidase 4-derived reactive ox...

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NOX4-Derived Reactive Oxygen Species Drive Apelin-13-Induced Vascular Smooth Muscle Cell Proliferation via the ERK Pathway

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