National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [21177052]; Foundation of National 863 Plan of China [2012AA063501]; Science and Technology Program of Hunan Province in China [2010SK3039]; Construct Program of the Key Discipline (Public Health and Preventive Medicine) in Hunan Province
机构署名：
本校为第一且通讯机构
院系归属：
公共卫生学院
摘要：
We report on a sensitive and specific method for the visual and colorimetric detection of 8-hydroxy-2′-deoxyguanosine (8-OHdG) in human urine by using the 8-OHdG-aptamer (Apt) as the recognition element. The aptamer was adsorbed on the surface of gold nanoparticles which enhances their stability. On addition of 8-OHdG, the conformation of the aptamer changes to form a G-quadruplex structure, thereby losing the ability to protect the nanoparticles and causing a color change from red to blue. The conformational changes were also studied by circu...
