The Laboratory fish has been widely used in pharmaceutical research as model organisms. The zebrafish is a classic animal model in basic research, which is always used for establishing human disease models and discovering lead drug due to its unique characteristics. Many valuable research achievement has been made on the study of zehrafish. In addition, Oryzias latipes, Oneorhynchu .smykis, Xiphophorus helleri, Gobioeypris rarus, Carassius auratus red variety, Carassius auratus, Cyprinus earpio and other fish also show its advantage in the development and application of drugs. The article summ...