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Chronic BPAF exposure differentially enhances fat deposition in mice fed normal or high-fat diets via lipid metabolism dysregulation

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成果类型:
期刊论文
作者:
Lv, Ziquan;Xu, Xinyue;Tang, Zhi;Liang, Yin;Peng, Changfeng;...
作者机构:
[Lv, Ziquan; Xu, Xinyue] School of Public Health, University of South China, Hengyang, Hunan Province, China
[Tang, Zhi] School of Public Health, Guangdong Medical University, Dongguan, China
[Liang, Yin; Jia, Guixuan; Guo, Yajie] Department of Emergency Medicine, The Eighth Affiliated Hospital, Sun Yat-sen University, Shenzhen, China
[Peng, Changfeng; Wu, Yuxuan; Hu, Xiaoxiao; Chen, Ying; Liu, Guangnan; Wang, Dan] Shenzhen Center for Disease Control and Prevention, Shenzhen, Guangdong Province, China
[Sang, Dan] Department of Endocrinology, The Eighth Affiliated Hospital, Sun Yat-Sen University, Shenzhen, China
语种:
英文
关键词:
BPAF;high-fat diet;Fat accumulation;Lipid Metabolism;Obesity
期刊:
FRONTIERS IN ENDOCRINOLOGY
ISSN:
1664-2392
年:
2025
卷:
16
页码:
1571076
机构署名:
本校为第一机构
院系归属:
公共卫生学院
摘要:
Background: Bisphenol AF (BPAF), an alternative to Bisphenol A (BPA), is increasingly utilized in various industrial applications, yet its toxicological profile remains incompletely understood. This study aims to investigate the impact of BPAF exposure on obesity and lipid metabolism in male mice subjected to either a normal chow diet (ND) or a high-fat diet (HFD).Methods: Mice were exposed to BPAF at a concentration of 100 μg/kg every other day for five months under different dietary conditions, and body weight, rectal temperature, and food i...

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