TiO2 nanosheets promote the transformation of vascular smooth muscle cells into foam cells in vitro and in vivo through the up-regulation of nuclear factor kappa B subunit 2

首页 > 成果 > 详情

认领

导出

Link by DOI

反馈

作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Li, Shuang;Yan, Dejian;Huang, Chaobo;Yang, Fei;Cao, Yi*

通讯作者：

Cao, Yi

作者机构：

[Li, Shuang; Yang, Fei; Cao, Yi] Univ South China, Sch Publ Hlth, Hengyang Med Sch, Hunan Prov Key Lab Typ Environm Pollut & Hlth Haz, Hengyang 421001, Peoples R China.

[Huang, Chaobo; Li, Shuang] Nanjing Forestry Univ NFU, Coll Chem Engn, Nanjing 210037, Peoples R China.

[Li, Shuang; Cao, Yi] Xiangtan Univ, Coll Chem, Key Lab Environm Friendly Chem & Applicat, Minist Educ,Lab Biochem, Xiangtan 411105, Peoples R China.

[Yan, Dejian] North China Elect Power Univ, Inst Adv Mat, Beijing 102206, Peoples R China.

通讯机构：

[Cao, Yi] U

Univ South China, Sch Publ Hlth, Hengyang Med Sch, Hunan Prov Key Lab Typ Environm Pollut & Hlth Haz, Hengyang 421001, Peoples R China.

语种：

英文

关键词：

*Lipid droplet biogenesis;*Nuclear factor kappa B subunit 2 (NFKB2);*TiO(2) nanosheets (NSs);*Transcriptomics;*Vascular smooth muscle cells (VSMCs)

期刊：

Journal of Hazardous Materials

ISSN：

0304-3894

年：

2022

卷：

424

期：

Pt D

页码：

127704

DOI：

10.1016/j.jhazmat.2021.127704

基金类别：

Ministry of Science and Technology of ChinaMinistry of Science and Technology, China [2016YFC0900802]; Key Research and Development Pro-jects in Hunan Province [2019SK2041]

机构署名：

本校为第一且通讯机构

院系归属：

公共卫生学院

摘要：

Titanium dioxide (TiO2) nanomaterials have been shown to promote atherosclerosis through endothelial dysfunction. This study investigated the toxicity of TiO2 nanosheets (NSs) to vascular smooth muscle cells (VSMCs), one of the pivotal cells involved in all stages of atherosclerosis. Only a high concentration of TiO2 NSs (128 μg/mL) modestly induced cytotoxicity by decreasing thiols. RNA-sequencing data revealed that 64 μg/mL TiO2 NSs significantly down-regulated 94 genes and up-regulated 174 genes, respectively. Gene ontology (GO) terms and ...

反馈

产权有误：本人成果被他人认领

数据有误：数据基本信息有误

归属有误：成果的院系归属、机构署名归属有误

其他原因：

验证码：

看不清楚，换一个

确定

取消

成果认领

标题：

用户	作者	通讯作者	--
	请选择	请选择	--

确定

取消

TiO2 nanosheets promote the transformation of vascular smooth muscle cells into foam cells in vitro and in vivo through the up-regulation of nuclear factor kappa B subunit 2

反馈

成果认领

提示

该栏目需要登录且有访问权限才可以访问