Manganese exposure causes movement deficit and changes in the protein profile of the external globus pallidus in Sprague Dawley rats

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Zhang, Kaiqin;He, Kaiwu;Xu, Jia;Nie, Lulin;Li, Shupeng;...

通讯作者：

Yang, Xifei

作者机构：

[Long, Dingxin; Zhang, Kaiqin] Univ South China, Sch Publ Hlth, Hengyang, Hunan, Peoples R China.

[He, Kaiwu; Nie, Lulin; Liu, Jianjun; Xu, Jia; Yang, Xifei; Zhang, Kaiqin] Shenzhen Ctr Dis Control & Prevent, Key Lab Modern Toxicol Shenzhen, Shenzhen Med Key Discipline Hlth Toxicol, 8 Longyuan Rd, Shenzhen 518055, Peoples R China.

[He, Kaiwu; Li, Shupeng] Peking Univ, Sch Chem Biol & Biotechnol, Shenzhen Grad Sch, Shenzhen, Peoples R China.

[Dai, Zhongliang] Jinan Univ, Shenzhen Peoples Hosp, Clin Med Coll 2, Dept Anesthesiol, Shenzhen, Peoples R China.

通讯机构：

[Yang, Xifei] S

Shenzhen Ctr Dis Control & Prevent, Key Lab Modern Toxicol Shenzhen, Shenzhen Med Key Discipline Hlth Toxicol, 8 Longyuan Rd, Shenzhen 518055, Peoples R China.

语种：

英文

关键词：

Movement deficit;manganism;signaling pathways;external globus pallidus;rats

期刊：

Toxicology and Industrial Health

ISSN：

0748-2337

年：

2021

卷：

期：

页码：

7482337211022223

DOI：

10.1177/07482337211022223

基金类别：

Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81673134]; Guangdong Provincial Key ST Program [2018B030336001]; Sanming Project of Medicine in Shenzhen [SZSM201611090]

机构署名：

本校为第一机构

院系归属：

公共卫生学院

摘要：

Manganese (Mn) is required for normal brain development and function. Excess Mn may trigger a parkinsonian movement disorder but the underlying mechanisms are incompletely understood. We explored changes in the brain proteomic profile and movement behavior of adult Sprague Dawley (SD) rats systemically treated with or without 1.0 mg/mL MnCl2 for 3 months. Mn treatment significantly increased the concentration of protein-bound Mn in the external globus pallidus (GP), as demonstrated by inductively coupled plasma mass spectrometry. Behavioral study showed that Mn treatment induced movement defic...

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Manganese exposure causes movement deficit and changes in the protein profile of the external globus pallidus in Sprague Dawley rats

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