期刊论文

Zuo, Wang

英文

Clinica Chimica Acta

0009-8981

2016

456

69-74

10.1016/j.cca.2016.02.026

Atherosclerosis is a multifactorial chronic disease caused by complex genetic and environmental factors. DNA methylation/demethylation modifications induced by environmental factors are important modulators of atherosclerosis. In the past few decades, the role of DNA methylation dynamics in the pathogenesis of atherosclerosis has been extensively studied. Numerous works showed that DNA methylation is associated with the pathological development of atherosclerosis (Fig. 2). The present results

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Atherosclerosis, a multifactorial disease of large- and intermediate-sized arteries, is characterized by the accumulation of lipids and the proliferation of arterial smooth muscle cells, chronic inflammatory cells, and fibrous materials. DNA methylation involves inherent and acquired gene transcription changes, which occur independently of the DNA sequence. DNA methylation in the genome plays a major role in the development and progression of atherosclerosis. DNA methylation is a distinct and crucial mechanism that regulates genes governing cel...