Advancements in clinical aspects of targeted therapy and immunotherapy in breast cancer

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Ye, Feng;Dewanjee, Saikat;Li, Yuehua;Jha, Niraj Kumar;Chen, Zhe-Sheng;...

通讯作者：

Tang, HL;Jha, SK;Behl, T

作者机构：

[Ye, Feng; Tang, Hailin] Sun Yat Sen Univ, State Key Lab Oncol South China, Canc Ctr, Guangzhou, Peoples R China.

[Dewanjee, Saikat] Jadavpur Univ, Dept Pharmaceut Technol, Adv Pharmacognosy Res Lab, Kolkata 700032, India.

[Li, Yuehua] Univ South China, Affiliated Hosp 1, Hengyang Med Sch, Dept Med Oncol, Hengyang, Peoples R China.

[Li, Yuehua] Univ South China, Inst Pathogen Biol, Hengyang Med Coll, Hengyang, Peoples R China.

[Jha, Niraj Kumar; Jha, SK; Jha, Saurabh Kumar] Sharda Univ, Sch Engn & Technol, Dept Biotechnol, Greater Noida, India.

通讯机构：

[Tang, HL ; Jha, SK ] S

[Behl, T ] U

Sun Yat Sen Univ, State Key Lab Oncol South China, Canc Ctr, Guangzhou, Peoples R China.

Sharda Univ, Sch Engn & Technol, Dept Biotechnol, Greater Noida, India.

Univ Petr & Energy Studies, Sch Hlth Sci & Technol, Dehra Dun, Uttaranchal, India.

语种：

英文

关键词：

Breast cancer;Clinical trials;Immune-checkpoint Inhibitors;Immunotherapy;Targeted therapies

期刊：

Molecular Cancer

ISSN：

1476-4598

年：

2023

卷：

期：

页码：

1-40

DOI：

10.1186/s12943-023-01805-y

基金类别：

This work was supported by funds from the National Natural Science Foundation of China (82203130, Feng Ye), the Science and Technology Program of Guangzhou (2023A04J1785, Feng Ye), the Key Research Project of Hunan Provincial Education Department (21A0270, Yuehua Li), and China Postdoctoral Science Foundation (2022M711541, Yuehua Li).

机构署名：

本校为其他机构

院系归属：

医学院

摘要：

Breast cancer is the second leading cause of death for women worldwide. The heterogeneity of this disease presents a big challenge in its therapeutic management. However, recent advances in molecular biology and immunology enable to develop highly targeted therapies for many forms of breast cancer. The primary objective of targeted therapy is to inhibit a specific target/molecule that supports tumor progression. Ak strain transforming, cyclin-dependent kinases, poly (ADP-ribose) polymerase, and different growth factors have emerged as potential therapeutic targets for specific breast cancer su...

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Advancements in clinical aspects of targeted therapy and immunotherapy in breast cancer

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