miR-429 regulates alveolar macrophage inflammatory cytokine production and is involved in LPS-induced acute lung injury

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成果类型：

期刊论文

作者：

Xiao, Ji*;Tang, Jing;Chen, Quan;Tang, Dan;Liu, Meimei;...

通讯作者：

Xiao, Ji

作者机构：

[Luo, Min; Tang, Dan; Zhao, Zhenyu; Tang, Jing; Wang, Deming; Chen, Quan; Wang, Jiazheng; Xiao, Ji; Wang, Yan] Univ South China, Affiliated Hosp 2, Dept Anesthesiol, Hengyang 421001, Hunan, Peoples R China.

[Tang, Jing] Maternal & Child Hlth Hosp Hunan Prov, Dept Anesthesiol, Changsha 410008, Hunan, Peoples R China.

[Liu, Meimei] Univ South China, Affiliated Hosp 2, Dept Paediat, Hengyang 421001, Hunan, Peoples R China.

[Tang, Chaoke; Mo, Zhongcheng] Univ South China, Life Sci Res Ctr, Inst Cardiovasc Res, Key Lab Atherosclerol Hunan Prov, Hengyang 421001, Hunan, Peoples R China.

通讯机构：

[Xiao, Ji] U

Univ South China, Affiliated Hosp 2, Dept Anesthesiol, Hengyang 421001, Hunan, Peoples R China.

语种：

英文

关键词：

cytokine;dual-specificity phosphatase 1;lipopolysaccharide;miR-429;mitogen-activated protein kinase

期刊：

BIOCHEMICAL JOURNAL

ISSN：

0264-6021

年：

2015

卷：

471

期：

页码：

281-291

DOI：

10.1042/BJ20131510

基金类别：

Hunan Provincial Science and Technology Department [2013FJ6006, 2013SK3114]; Hunan Provincial Natural Science Foundation of ChinaNatural Science Foundation of Hunan Province [11JJ3120]; National Natural Sciences Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81301625, 81100211]; construct programme of the key discipline in Hunan Province, China (Basic Medicine Sciences in University of South China)

机构署名：

本校为第一且通讯机构

院系归属：

国防科学技术学院

医学院

药学与生物科学学院

摘要：

P38 MAPK (mitogen-activated protein kinase) is a critical regulator in lung inflammation. It can be inactivated by DUSP1 (dual-specificity phosphatase 1) which was identified as a putative target of miR-429. miR-429 mimics directly targeted to the 3'-UTR of the gene encoding DUSP1 may result in the translational attenuation of DUSP1. Moreover, the phosphorylation of p38 MAPK was prolonged after miR-429 mimic treatment. Additionally, miR-429 expression was sensitive to LPS (lipopolysaccharide) stimulation and the miR-429 mimics increased the pro...

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miR-429 regulates alveolar macrophage inflammatory cytokine production and is involved in LPS-induced acute lung injury

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