The comparison with 13C-NMR standard spectra is an important method for identifying natural alkaloids. The simulation comparison can also identify unknown compounds without 13C-NMR standard spectra. In this paper, 13C-NMR chemical shifts of quinoline alkaloids are systematically studied with experimental substituent parameters of the model compound. The results indicate that the substituents parameters of the model compound correlate linearly with chemical shifts of the corresponding quinoline derivatives very well. The substituent effect factor and quantitative model are put forward theoretic...