Chlamydia psittaci Plasmid-Encoded CPSIT_P7 Elicits Inflammatory Response in Human Monocytes via TLR4/Mal/MyD88/NF-κB Signaling Pathway

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成果类型：

期刊论文

作者：

Chen, Qian;Li, Yumeng;Yan, Xiaoliang;Sun, Zhenjie;Wang, Chuan;...

通讯作者：

Wu, Yimou

作者机构：

[Lu, Chunxue; Wu, Yimou; Li, Yumeng; Yan, Xiaoliang; Wang, Chuan; Sun, Zhenjie; Xiao, Jian; Chen, Qian] Univ South China, Hunan Prov Cooperat Innovat Ctr Mol Target New Dr, Hunan Prov Key Lab Special Pathogens Prevent & Co, Inst Pathogen Biol,Hengyang Med Coll, Hengyang, Peoples R China.

[Chen, Qian] Univ South China, Affiliated Hosp 1, Inst Clin Res, Hengyang, Peoples R China.

[Liu, Shuangquan] Univ South China, Affiliated Hosp 1, Dept Clin Lab, Hengyang, Peoples R China.

通讯机构：

[Wu, Yimou] U

Univ South China, Hunan Prov Cooperat Innovat Ctr Mol Target New Dr, Hunan Prov Key Lab Special Pathogens Prevent & Co, Inst Pathogen Biol,Hengyang Med Coll, Hengyang, Peoples R China.

语种：

英文

关键词：

Key word: Chlamydia psittaci;CPSIT_P7;human monocytes;TLR4;Inflammation

期刊：

Frontiers in Microbiology

ISSN：

1664-302X

年：

2020

卷：

页码：

578009

DOI：

10.3389/fmicb.2020.578009

基金类别：

This project was supported by the National Natural Science Foundation of China under Grant Nos. 81671986 and 31872643, the Hunan Provincial Key Laboratory for Special Pathogens Prevention and Control Foundation under Grant No. 2014-5, and the Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study (2015-351).

机构署名：

本校为第一且通讯机构

院系归属：

医学院

药学与生物科学学院

摘要：

The chlamydial plasmid, an essential virulence factor, encodes plasmid proteins that play important roles in chlamydial infection and the corresponding immune response. However, the virulence factors and the molecular mechanisms of Chlamydia psittaci are not well understood. In the present study, we investigated the roles and mechanisms of the plasmid-encoded protein CPSIT_P7 of C. psittaci in regulating the inflammatory response in THP-1 cells (human monocytic leukemia cell line). Based on cytokine arrays, CPSIT_P7 induces the expression of in...

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Chlamydia psittaci Plasmid-Encoded CPSIT_P7 Elicits Inflammatory Response in Human Monocytes via TLR4/Mal/MyD88/NF-κB Signaling Pathway

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