The Zinc Transporter SLC39A10 Plays an Essential Role in Embryonic Hematopoiesis

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成果类型：

期刊论文

作者：

He, Xuyan;Ge, Chaodong;Xia, Jun;Xia, Zhidan;Zhao, Lu;...

作者机构：

[Zhao, Lu; Huang, Sicong; Min, Junxia; Xia, Jun; Wang, Rong; Pan, Jianwei; He, Xuyan; Wang, Fudi; Ge, Chaodong] Zhejiang Univ, Affiliated Hosp 1, Affiliated Hosp 2, Inst Translat Med,Sch Publ Hlth,Sch Med,State Key, Hangzhou 310058, Peoples R China.

[He, Xuyan; Wang, Fudi] Univ South China, Affiliated Hosp 1, Sch Publ Hlth, Basic Med Sci,Hengyang Med Sch, Hengyang 421001, Peoples R China.

[Xia, Jun] Chinese Acad Sci, Univ Chinese Acad Sci, Inst Stem Cell & Regenerat, Inst Zool,State Key Lab Membrane Biol, Beijing 100101, Peoples R China.

[Xu, Peng-Fei; Cheng, Tao] Zhejiang Univ, Womens Hosp, Sch Med, Hangzhou 310058, Zhejiang, Peoples R China.

[Xu, Peng-Fei; Cheng, Tao] Zhejiang Univ, Inst Genet, Sch Med, Hangzhou 310058, Zhejiang, Peoples R China.

语种：

英文

关键词：

HSPCs;SLC39A10;ZIP10;anemia;hematopoiesis;hematopoietic stem cells;zinc homeostasis

期刊：

Advanced Science

ISSN：

2198-3844

年：

2023

卷：

期：

页码：

2370107-

DOI：

10.1002/advs.202205345

基金类别：

National Natural Science Foundation of China [31930057, 31970689, 31971088]; National Key Research and Development Program of China [2018YFA0507801, 2018YFA0507802]

机构署名：

本校为其他机构

院系归属：

公共卫生学院

摘要：

Slc39a10 (Zip10), as a zinc transporter, plays an essential role in the survival of fetal hematopoietic stem/progenitor cells in both zebrafish and mice. Loss of Slc39a10 causes impaired hematopoiesis that can be rescued by zinc supplementation or inhibiting necroptosis. This study shows that Slc39a10 promotes the development of fetal hematopoietic stem cells by maintaining zinc homeostasis. Abstract The role of zinc in hematopoiesis is currently unclear. Here, SLC39A10 (ZIP10) is identified as a key zinc transporter in hematopoiesis. The resul...

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