Synthesis and antioxidant activity of curcumin analogs

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Zheng, Qu-Tong;Yang, Ze-Hua;Yu, Liu-Ying;Ren, Yu-Yan;Huang, Qiu-Xia;...

通讯作者：

Wang, Zong-Bao;Zheng, Xing

作者机构：

[Wang, ZB; Zheng, Xing; Yang, Ze-Hua; Ma, Xiang-Yu; Yu, Liu-Ying; Wang, Zong-Bao; Ren, Yu-Yan; Huang, Qiu-Xia; Chen, Zi-Kang; Liu, Qiu; Zheng, Qu-Tong] Univ South China, Inst Pharm & Pharmacol, Hengyang 421001, Peoples R China.

[Wang, ZB; Zheng, Xing; Yang, Ze-Hua; Ma, Xiang-Yu; Yu, Liu-Ying; Wang, Zong-Bao; Ren, Yu-Yan; Huang, Qiu-Xia; Chen, Zi-Kang; Liu, Qiu; Zheng, Qu-Tong] Hunan Prov Cooperat Innovat Ctr Mol Target New Dr, Hengyang 421001, Peoples R China.

[Chen, Zi-Kang; Liu, Qiu] Univ South China, Res Interest Grp Pharm, Hengyang 421001, Peoples R China.

通讯机构：

[Wang, ZB; Zheng, X] U

[Wang, ZB; Zheng, X] H

Univ South China, Inst Pharm & Pharmacol, Hengyang 421001, Peoples R China.

Hunan Prov Cooperat Innovat Ctr Mol Target New Dr, Hengyang 421001, Peoples R China.

语种：

英文

关键词：

Curcumin;antioxidant activity;structure modification;structure–activity relationship

期刊：

亚洲天然物产研究(英文版)

ISSN：

1028-6020

年：

2017

卷：

期：

页码：

489-503

DOI：

10.1080/10286020.2016.1235562

基金类别：

National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81273537]; Hunan Provincial Education DepartmentHunan Provincial Education Department [12K095]; key disciplines of Hunan Province; Zhengxiang scholar program of the University of South China

机构署名：

本校为第一且通讯机构

院系归属：

药学与生物科学学院

摘要：

Numerous biological activities including antioxidant, antitumor, anti-inflammation, and antivirus of the natural product curcumin were reported. However, the clinical application of it was significantly limited by its instability, poor solubility, less body absorbing, and low bioavailability. This review focuses on the structure modification and antioxidant activity evaluation of curcumin. To study the structure–activity relationship (SAR), five series of curcumin analogs were synthesized and their antioxidant activity were evaluated in vitro....

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Synthesis and antioxidant activity of curcumin analogs

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