期刊论文

中文

中国新药杂志

1003-3734

2007

16

8

607-609

10.3321/j.issn:1003-3734.2007.08.009

国家自然科学基金(30572191) 湖南省卫生厅科研课题资助(B200508)

本校为第一机构

目的:探讨甲醛对植入后小鼠胚胎发育毒性及时间-效应关系.方法:应用体外全胚胎培养模型,观察终浓度为81μmol·L-1的甲醛与昆明种小鼠全胚胎共培养不同时间(分别为0,16,26,48 h)对胚胎生长发育的影响.结果:甲醛对小鼠胚胎的器官形成早期具有明显的影响,呈现明显的时间-效应关系.甲醛暴露16 h则能引起胚胎发育迟缓.当甲醛暴露时间为26和48 h时,胚胎生长发育和形态分化等各项指标与对照组(0 h)比较均呈现出显著差异(P＜0.05,P＜0.01);胚胎畸形发生率也显著升高,主要表现为神经管闭合不全、体位翻转不全、脑、心脏、腮弓发育异常及视觉系统、前肢芽、后肢芽、体节等畸形.结论:甲醛对小鼠胚胎生长发...

Objective： To study the time-effect relationship of mice embryonic toxicity and terato- genicity induced by HCHO in vitro, nethods：Kunming mice embryos （8.5 days old） were incubated to- gether with formaldehyde （81μmol.L^-1）for 0, 16, 26 or 48 hours, respectively. The development of mice embryos was then assessed. Results：Formaldehyde degenerated early embryonic growth in a time- dependent manner. The embryonic development was significantly retarded post a 16-hours exposure of formaldehyde. The embryonic development and histomorphologic...