Apelin attenuates depressive-like behavior and neuroinflammation in rats co-treated with chronic stress and lipopolysaccharide

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成果类型：

期刊论文

作者：

Zhang, Zi-xuan;Li, E.;Yan, Jian-ping;Fu, Wan;Shen, Pei;...

通讯作者：

You, Yong;Tian, Shao-Wen

作者机构：

[Zhang, Zi-xuan; You, Yong] Hainan Med Univ, Affiliated Hosp 2, Dept Neurol, Haikou 571199, Hainan, Peoples R China.

[Zhang, Zi-xuan] XiangTan Cent Hosp, Dept Neurol, Xiangtan 411100, Hunan, Peoples R China.

[Li, E.] Chinese Acad Sci, Inst Neurosci, CAS Ctr Excellence Brain Sci & Intelligence Techn, Shanghai 200031, Peoples R China.

[Tian, Shao-Wen] Univ South China, Hengyang Med Coll, Dept Physiol, Hengyang 421001, Hunan, Peoples R China.

[Shen, Pei; Fu, Wan; Yan, Jian-ping] Univ South China, Affiliated Hosp 1, Dept Neurol, Hengyang 421001, Hunan, Peoples R China.

通讯机构：

[You, Yong] H

[Tian, Shao-Wen] U

Hainan Med Univ, Affiliated Hosp 2, Dept Neurol, Haikou 571199, Hainan, Peoples R China.

Univ South China, Hengyang Med Coll, Dept Physiol, Hengyang 421001, Hunan, Peoples R China.

语种：

英文

期刊：

Neuropeptides

ISSN：

0143-4179

年：

2019

卷：

页码：

101959

DOI：

10.1016/j.npep.2019.101959

机构署名：

本校为通讯机构

院系归属：

医学院

摘要：

Several experimental studies have proved that activation of neuroinflammation pathways may contribute to the development of depression, a neuropsychiatric disorder disease. Our previous studies have shown the antidepressant properties of apelin, but the mechanism was unkown. This study was performed to verify whether the antidepressant effect of apelin was related to its anti-inflammation effect in the central nervous system. To achieve our aim, we selected the co-treatment of chronic stress and LPS to induced an inflammatory process in rats. The effect of this co-treatment was evaluated throu...

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Apelin attenuates depressive-like behavior and neuroinflammation in rats co-treated with chronic stress and lipopolysaccharide

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