A Sensitive Assay Enriched with Blue/White Screening to Empower Sequencing Analysis for G > A Hotspot Mutation in Codon 13 of KRAS Gene

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成果类型：

期刊论文

作者：

Zhou, Cuilan;Pu, WangYang;Peng, Cuiying;Li, Wen;Xiao, Li;...

通讯作者：

Cai, Weijun;Li, Kai

作者机构：

[Zhou, Cuilan; Cai, Weijun; Liao, Duanfang] Cent S Univ, Sch Basic Med, Dept Histol & Embryol, Changsha 410078, Hunan, Peoples R China.

[Zhou, Cuilan; Peng, Cuiying] Univ South China, Dept Human Anat, Hengyang 421001, Peoples R China.

[Li, Kai; Xing, Chungen; Li, Wen; Sirois, Pierre; Xu, Huifen; Xiao, Li; Pu, WangYang] Soochow Univ, Dept Mol Diagnost & Biopharmaceut, Coll Pharmaceut Sci, Suzhou 215123, Peoples R China.

[Lu, Guangming] Nanjing Univ, Jinling Hosp, Dept Med Imaging, Med Sch, Nanjing 210093, Jiangsu, Peoples R China.

[He, Nongyue] Southeast Univ, Sch Biol Sci & Med Engn, State Key Lab Bioelect, Nanjing 210096, Jiangsu, Peoples R China.

通讯机构：

[Cai, Weijun] C

[Li, Kai] S

Cent S Univ, Sch Basic Med, Dept Histol & Embryol, Changsha 410078, Hunan, Peoples R China.

Soochow Univ, Dept Mol Diagnost & Biopharmaceut, Coll Pharmaceut Sci, Suzhou 215123, Peoples R China.

语种：

英文

关键词：

KRAS;Sanger's Sequencing;Blue/White Screening;ctDNA;Cancer Test

期刊：

JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY

ISSN：

1533-4880

年：

2017

卷：

期：

页码：

9176-9181

DOI：

10.1166/jnn.2017.13912

基金类别：

National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81370248]; Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD); Jiangsu Province Clinical Medical Science and Technology Program [BL2013016]

机构署名：

本校为其他机构

院系归属：

医学院

摘要：

KRAS (Kirsten rat sarcoma viral oncogene homolog) mutations are associated with the development of many types of cancers and are also related to the cancer sensitivities to selected drugs. Genetic testing of KRAS mutation using cancer tissues has been well developed, but assays targeting circulating tumor DNA (ctDNA) of KRAS mutations are to be developed in order to meet the requirements for clinical applications. This study tested the possibilities of applying blue/white screening technology in analyzing point mutations at codon 13 of KRAS gene. The present study has documented that the combi...

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A Sensitive Assay Enriched with Blue/White Screening to Empower Sequencing Analysis for G > A Hotspot Mutation in Codon 13 of KRAS Gene

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