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LY2874455 potently inhibits FGFR gatekeeper mutants and overcomes mutation-based resistance

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成果类型:
期刊论文
作者:
Wu, Daichao;Guo, Ming;Min, Xiaoli;Dai, Shuyan;Li, Meixiang;...
通讯作者:
Chen, Yongheng
作者机构:
[Chen, Xiaojuan; Jiang, Longying; Min, Xiaoli; Chen, Zhuchu; Li, Jun; Dai, Shuyan; Qu, Lingzhi; Wu, Daichao; Chen, Yongheng; Guo, Ming; Zhou, Zhan] Cent S Univ, XiangYa Hosp, Lab Struct Biol, Key Lab Canc Prote,Chinese Minist Hlth, Changsha 410008, Hunan, Peoples R China.
[Tan, Sijie; Li, Meixiang; Wu, Daichao; Li, Guoqing] Univ South China, Inst Clin Anat & Reprod Med, Dept Histol & Embryol, Med Coll, Hengyang 421001, Hunan, Peoples R China.
[Ma, Yao] Univ South China, Network Informat Ctr, Hengyang 421001, Hunan, Peoples R China.
[Chen, Lin] Univ Southern Calif, Dept Biol Sci, Mol & Computat Biol, Los Angeles, CA 90089 USA.
[Xu, Guangyu] Hunan Normal Univ, Coll Chem & Chem Engn, Key Lab Chem Biol & Tradit Chinese Med Res, Minist Educ, Changsha 410081, Hunan, Peoples R China.
通讯机构:
[Chen, Yongheng] C
Cent S Univ, XiangYa Hosp, Lab Struct Biol, Key Lab Canc Prote,Chinese Minist Hlth, Changsha 410008, Hunan, Peoples R China.
语种:
英文
期刊:
Chemical Communications
ISSN:
1359-7345
年:
2018
卷:
54
期:
85
页码:
12089-12092
机构署名:
本校为其他机构
院系归属:
医学院
摘要:
The chemical compound LY2874455 has the potential to overcome drug resistance driven by FGFR gatekeeper mutations. X-ray crystallographic studies provide the structural explanation for why this compound is effective against ...

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