Nanohydroxyapatite/cellulose nanocrystals/silk fibroin ternary scaffolds for rat calvarial defect regeneration

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成果类型：

期刊论文

作者：

Chen, Xiaoming;Zhou, Runmei;Chen, Bin;Chen, Jianting*

通讯作者：

Chen, Jianting

作者机构：

[Chen, Jianting; Chen, Xiaoming] Southern Med Univ, Nanfang Hosp, Dept Orthoped Spinal Surg, Guangzhou 510515, Guangdong, Peoples R China.

[Chen, Xiaoming] Univ South China, Affiliated Hosp 2, Dept Orthoped Spinal Surg, Hengyang 421001, Peoples R China.

[Zhou, Runmei] Univ South China, Affiliated Hosp 2, Dept Pharm, Hengyang 421001, Peoples R China.

[Chen, Bin] Chenzhou 1 Peoples Hosp, Dept Orthoped Spinal Surg, Chenzhou 423000, Peoples R China.

通讯机构：

[Chen, Jianting] S

Southern Med Univ, Nanfang Hosp, Dept Orthoped Spinal Surg, Guangzhou 510515, Guangdong, Peoples R China.

语种：

英文

期刊：

RSC Advances

ISSN：

2046-2069

年：

2016

卷：

期：

页码：

35684-35691

DOI：

10.1039/c6ra02038k

机构署名：

本校为其他机构

院系归属：

药学与生物科学学院

摘要：

The purpose of this study was to design and characterise a novel biomimetic scaffold for the repair of critical size calvarial defects. In this study, we developed a new hydroxyapatite/cellulose nanocrystals/silk fibroin (HA/CNC/SF) scaffold by mixing a solution of SF with HA and CNC nanoparticles. The scaffold was fabricated by freeze-drying. The average pore size and porosity of the HA/CNC/SF scaffolds were 110 ± 7.3 μm and 90 ± 6.2%, respectively. The thermostability and mechanical properties of the scaffolds were significantly better tha...

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Nanohydroxyapatite/cellulose nanocrystals/silk fibroin ternary scaffolds for rat calvarial defect regeneration

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