Recent advances in polymer-based drug delivery systems for local anesthetics

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成果类型：

期刊论文

作者：

Wang, Bo;Wang, Shuo;Zhang, Qi;Deng, Yixuan;Li, Xiang;...

通讯作者：

Kuang, Xin;Sheng, Shihou;Yu, Yingjie

作者机构：

[Kuang, Xin; Wang, Bo; Deng, Yixuan; Peng, Liangyu; Li, Xiang] Univ South China, Affiliated Hosp 1, Dept Anesthesiol, Hengyang 421001, Hunan, Peoples R China.

[Wang, Shuo] PLA Rocket Force Characterist Med Ctr, Dept Pharm, Beijing 100088, Peoples R China.

[Zhang, Qi] NYU, Dept Chem & Biomol Engn, Brooklyn, NY 11201 USA.

[Zuo, Xianghao] SUNY Stony Brook, Dept Mat Sci & Chem Engn, Stony Brook, NY 11794 USA.

[Piao, Meihua] Jilin Univ, Hosp 1, Dept Anesthesiol, Changchun 130021, Jilin, Peoples R China.

通讯机构：

[Kuang, Xin] U

[Sheng, Shihou] J

[Yu, Yingjie] S

Univ South China, Affiliated Hosp 1, Dept Anesthesiol, Hengyang 421001, Hunan, Peoples R China.

Jilin Univ, China Japan Union Hosp, Dept Gastrointestinal Surg, Changchun 130033, Jilin, Peoples R China.

语种：

英文

关键词：

Drug delivery system;Local anesthetics;Polymer

期刊：

Acta Biomaterialia

ISSN：

1742-7061

年：

2019

卷：

页码：

55-67

DOI：

10.1016/j.actbio.2019.05.044

基金类别：

This work was supported by Hunan Provincial and Municipal Joint Funds (NO. 2017JJ4049).

机构署名：

本校为第一且通讯机构

院系归属：

医学院

摘要：

Local anesthetics, which cause temporary loss of pain by inhibiting the transmission of nerve impulses, have been widely used in clinical practice. However, neurotoxicity and short half-lives have significantly limited their clinical applications. To overcome those barriers, numerous drug delivery systems (DDS) have been designed to encapsulate local anesthetic agents, so that large doses can be released slowly and provide analgesia over a prolonged period. So far, multiple classes of local anesthetic carriers have been investigated, with some ...

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