This work was supported by the National Natural Science Foundation of China (Grant No. 81172890 ), Hunan Provincial Key Laboratory for Special Pathogens Prevention and Control Foundation (Grant No. 2014-5 ), Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study (Grant No. 2015-351 ).
机构署名：
本校为第一机构
院系归属：
医学院
公共卫生学院
摘要：
Neisseria meningitidis (N. meningitidis) is a human-specific pathogen and a major cause of meningitis and septicemia with a high case fatality rate. N. meningitidis may penetrate the nasopharyngeal mucosal membrane and cause severe meningitis, a mucosal immune response plays a key role in the defense against meningococcal infections. Our previous study demonstrated that N. meningitidis serogroup B 0315 (NMB0315) was a vaccine candidate against N. meningitidis serogroup B (NMB) through parenteral immunization. In this study, immunopotentiators (...
