Upregulation of peroxiredoxin III in doxorubicin-induced cytotoxicity and the FoxO3a-dependent expression in H9c2 cardiac cells

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Liu, Mi-Hua*;Zhang, Yuan;He, Jun;Tan, Tian-Ping;Wu, Shao-Jian;...

通讯作者：

Liu, Mi-Hua

作者机构：

[Tan, Tian-Ping; Wu, Shao-Jian; Liu, Mi-Hua; He, Jun; Lin, Xiao-Long; Le, Qun-Fang; Chen, Yu-Dan; Fu, Hong-Yun; Liu, Jun] Univ South China, Affiliated Nanhua Hosp, Dept Clin Lab, Hengyang 421001, Hunan, Peoples R China.

[Zhang, Yuan] Hunan Mawangdui Hosp, Dept Pathol, Changsha 410016, Hunan, Peoples R China.

[Hu, Heng-Jing] Cent S Univ, Xiangya Hosp 2, Dept Cardiol, Cardiac Catheterisat Lab, Changsha 410011, Hunan, Peoples R China.

[Yuan, Cong] First Hosp Changsha, Dept Cardiol, Changsha 410005, Hunan, Peoples R China.

[Lin, Xiao-Long] Guangzhou Med Univ, Peoples Hosp Huizhou 3, Dept Pathol, Huizhou 516002, Guangdong, Peoples R China.

通讯机构：

[Liu, Mi-Hua] U

Univ South China, Affiliated Nanhua Hosp, Dept Clin Lab, 336 Dongfeng South Rd, Hengyang 421001, Hunan, Peoples R China.

语种：

英文

关键词：

FoxO3a;cardiomyocytes;doxorubicin;peroxiredoxin III

期刊：

EXPERIMENTAL AND THERAPEUTIC MEDICINE

ISSN：

1792-0981

年：

2015

卷：

期：

页码：

1515-1520

DOI：

10.3892/etm.2015.2693

基金类别：

Medical Scientific Research Funds of Guangdong province [A2014810]; Graduate Student Research Innovation Project of Hunan province [CX2013B397]

机构署名：

本校为第一且通讯机构

院系归属：

医学院

摘要：

Doxorubicin (DOX) is an efficient drug used in cancer therapy; however, it produces reactive oxygen species (ROS) that induce severe cytotoxicity, limiting its clinical application. The aim of the present study was to investigate the role of peroxiredoxin III (Prx III) in DOX-induced H9c2 cell injuries. Following DOX treatment, the expression of phosphorylated-FoxO3a (p-FoxO3a) was decreased and Prx III expression was increased in H9c2 cells. In order to detect whether oxidative stress was involved in the induction of Prx III expression by FoxO...

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Upregulation of peroxiredoxin III in doxorubicin-induced cytotoxicity and the FoxO3a-dependent expression in H9c2 cardiac cells

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