Chronic exposure to low-dose MC-LR induces ileal inflammation in mice through the PI3K/AKT/mTOR pathway

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成果类型：

期刊论文

作者：

Yang, Mingjie;Zheng, Shuilin;Zeng, Wen;Zhan, Chunhua;Yang, Yue*;...

通讯作者：

Yang, Yue;Yang, F;Yang, Y

作者机构：

[Yang, F; Yang, Yue; Yang, Fei; Yang, Mingjie; Zhan, Chunhua] Univ South China, Sch Publ Hlth, Hengyang Med Sch, Hengyang, Peoples R China.

[Zheng, Shuilin] Changsha Ctr Dis Control & Prevent, Changsha, Peoples R China.

[Yang, Yue; Zeng, Wen] Cent Hosp Shaoyang, Dept Publ Hlth, Shaoyang, Peoples R China.

[Yang, F; Yang, Fei] Univ South China, Nanhua Hosp, Hengyang Med Sch, Nucl Med Dept, Hengyang, Peoples R China.

通讯机构：

[Yang, F ; Yang, Y] U

[Yang, Y ] C

Univ South China, Sch Publ Hlth, Hengyang Med Sch, Hengyang, Peoples R China.

Cent Hosp Shaoyang, Dept Publ Hlth, Shaoyang, Peoples R China.

Univ South China, Nanhua Hosp, Hengyang Med Sch, Nucl Med Dept, Hengyang, Peoples R China.

语种：

英文

期刊：

JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A-CURRENT ISSUES

ISSN：

1528-7394

年：

2025

卷：

期：

页码：

364-372

DOI：

10.1080/15287394.2024.2441294

基金类别：

Hunan Province Key Research and Development Projects [2022SK2089]; Hunan Provincial Natural Science Youth Fund [2024JJ6392]; Chinese Center for Disease Control and Prevention [BZ2023-Q048]

机构署名：

本校为第一且通讯机构

院系归属：

公共卫生学院

摘要：

The global phenomenon of cyanobacterial bloom pollution is spreading globally due to climate change and eutrophication. It is well established that harmful cyanobacteria produce a wide range of toxins including microcystin-LR (MC-LR), a cyclic heptapeptide toxin known to damage various organs. The intestinal tract is the main site of MC-LR absorption and one of the targets susceptible to toxicity. Currently, studies on the enterotoxic effects of MC-LR predominantly focused on the colorectum, with limited investigations addressing the impact of ...

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Chronic exposure to low-dose MC-LR induces ileal inflammation in mice through the PI3K/AKT/mTOR pathway

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