Tea polyphenols alleviate tri-ortho-cresyl phosphate-induced autophagy of mouse ovarian granulosa cells

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成果类型：

期刊论文

作者：

Yang, Si;Shao, Shuxin;Huang, Boshu;Yang, Dan;Zeng, Lin;...

通讯作者：

Wang, Jinglei

作者机构：

[Yang, Si; Yang, Dan; Gan, Yu; Wang, Jinglei; Shao, Shuxin; Zeng, Lin; Chen, Jiaxiang] Nanchang Univ, Med Coll, Dept Physiol, 461 Bayi Rd, Nanchang 330006, Jiangxi, Peoples R China.

[Yang, Si; Wang, Jinglei; Chen, Jiaxiang] Jiangxi Prov Key Lab Reprod Physiol & Pathol, Nanchang, Jiangxi, Peoples R China.

[Shao, Shuxin] Gongqing Inst Sci & Technol, Nursing Sch, Gongqing, Peoples R China.

[Huang, Boshu] Nanchang Univ, Sch Publ Hlth, Nanchang, Jiangxi, Peoples R China.

[Long, Dingxin] Univ South China, Sch Publ Hlth, Hengyang, Peoples R China.

通讯机构：

[Wang, Jinglei] N

Nanchang Univ, Med Coll, Dept Physiol, 461 Bayi Rd, Nanchang 330006, Jiangxi, Peoples R China.

语种：

英文

关键词：

autophagy;granulosa cells;oxidative stress;tea polyphenols;tri-ortho-cresyl phosphate

期刊：

ENVIRONMENTAL TOXICOLOGY

ISSN：

1520-4081

年：

2020

卷：

期：

页码：

478-486

DOI：

10.1002/tox.22883

基金类别：

Young Scientist Training Project of Jiangxi Province, China [20153BCB23032]; Natural Science Foundation of Jiangxi ProvinceNatural Science Foundation of Jiangxi Province [20142BAB205001]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China [81360098, 81660246, 81660255]

机构署名：

本校为其他机构

院系归属：

公共卫生学院

摘要：

Tri-ortho-cresyl phosphate (TOCP), a widely used plasticizer in industry, can cause female reproductive damage. Tea polyphenols (TPs) have multiple health effects via inhibiting oxidative stress. However, the reproductive protection of TPs in TOCP-induced female reproductive system damage is yet to be elucidated. In the study, TOCP inhibited cell viability and induced autophagy of mouse ovarian granulosa cells; while TPs could rescue the inhibition of viability and induction of autophagy. 3-MA, an autophagy inhibitor, could also rescue the inhibition of cell viability. These results indicated ...

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Tea polyphenols alleviate tri-ortho-cresyl phosphate-induced autophagy of mouse ovarian granulosa cells

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