Objective To question whether No-1886, a synthetic compound, decreases plasma glucose and free fatty acids or improves pathological changes in diabetic Guizhou Minipigs induced by high sucrose and high fat feed. Methods 15 Guizhou Minipigs about 3-4 months were randomly divided into 3 groups of normal control, diabetes, diabetes treatment, which were fed by basal diet,high sucrose and high fat feed or with 1.0% No-1886 respectively.The concentration of plasma glucose and free fatty acids of minipigs,which were fasting the previous night,were analyzed in the 0,2,3,4,5,6,8th month respectively.T...