A novel ELISA using a recombinant outer membrane protein, rTp0663, as the antigen for serological diagnosis of syphilis

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成果类型：

期刊论文

作者：

Xu, Man;Xie, Yafeng;Jiang, Chuanhao;Xiao, Yongjian;Kuang, Xingxing;...

通讯作者：

Wu, Yimou

作者机构：

[Jiang, Chuanhao; Wu, Yimou; Zhao, Feijun; Li, Li; Xie, Yafeng; Kuang, Xingxing; Liang, Mingxing; Wang, Chuan; Xu, Man; Xiao, Yongjian; Zeng, Tiebing] Univ South China, Inst Pathogen Biol, Coll Med, Hengyang 421001, Peoples R China.

[Jiang, Chuanhao; Wu, Yimou; Zhao, Feijun; Li, Li; Xie, Yafeng; Kuang, Xingxing; Liang, Mingxing; Wang, Chuan; Xu, Man; Xiao, Yongjian; Zeng, Tiebing] Univ South China, Hunan Prov Cooperat Innovat Ctr Mol Target New Dr, Hengyang 421001, Peoples R China.

[Jiang, Chuanhao; Wu, Yimou; Zhao, Feijun; Li, Li; Xie, Yafeng; Kuang, Xingxing; Liang, Mingxing; Wang, Chuan; Xu, Man; Xiao, Yongjian; Zeng, Tiebing] Univ South China, Hunan Prov Key Lab Special Pathogens Prevent & Co, Hengyang 421001, Peoples R China.

[Xiao, Yongjian] Univ South China, Affiliated Hosp 2, Dept Clin Lab, Hengyang 421001, Peoples R China.

[Liu, Shuangquan] Univ South China, Affiliated Hosp 1, Dept Clin Lab, Hengyang 421001, Peoples R China.

通讯机构：

[Wu, Yimou] U

Univ South China, Inst Pathogen Biol, Coll Med, Hengyang 421001, Peoples R China.

语种：

英文

关键词：

Treponema pallidum;Syphilis;Serodiagnosis;Recombinant antigen;Tp0663;ELISA

期刊：

International Journal of Infectious Diseases

ISSN：

1201-9712

年：

2016

卷：

页码：

51-57

DOI：

10.1016/j.ijid.2015.12.013

基金类别：

This work was supported by the National Natural Science Foundation of China (grant numbers 81471576, 81201331, 30800996, and 81373230), the Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study (2015-351), the Hunan Provincial Key Laboratory for Special Pathogens Prevention and Control Foundation (grant number 2014-5), and the General Project in Hunan Province Science and Technology Program (grant number 2014TT2025).

机构署名：

本校为第一且通讯机构

院系归属：

医学院

药学与生物科学学院

摘要：

Background: The lack of Treponema pallidum-specific antigens with highly accurate diagnosis makes the diagnosis of syphilis challenging. Methods: A soluble recombinant version of a new diagnostic protein Tp0663 has been produced. The serodiagnostic potential of this protein was assessed by screening 3326 serum samples simultaneously evaluated by rapid plasma reagin and T. pallidum particle agglutination tests. Kappa (κ) coefficients were used to compare the concordance between clinical diagnosis and the Tp0663-based ELISA or the ARCHITECT Syph...

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A novel ELISA using a recombinant outer membrane protein, rTp0663, as the antigen for serological diagnosis of syphilis

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