Premature termination of DNA Damage Repair by 3-Methyladenine potentiates cisplatin cytotoxicity in nasopharyngeal carcinoma cells

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成果类型：

期刊论文

作者：

Zhou, Jie;Liu, Sisi;Deng, Jiali;He, Longmei;Jiang, Binyuan

通讯作者：

Jiang, BY

作者机构：

[Zhou, Jie; He, Longmei; Jiang, Binyuan; Deng, Jiali; Liu, Sisi] Univ South China, Affiliated Changsha Cent Hosp, Hengyang Med Sch, Dept Clin Lab, Changsha, Hunan, Peoples R China.

[He, Longmei] Univ South China, Affiliated Changsha Cent Hosp, Med Res Ctr, Hengyang Med Sch, Changsha, Hunan, Peoples R China.

[Jiang, Binyuan] Univ South China, Affiliated Changsha Cent Hosp, Hengyang Med Sch, Clin Trials Off, Changsha, Hunan, Peoples R China.

通讯机构：

[Jiang, BY ] U

Univ South China, Affiliated Changsha Cent Hosp, Hengyang Med Sch, Dept Clin Lab, Changsha, Hunan, Peoples R China.

Univ South China, Affiliated Changsha Cent Hosp, Hengyang Med Sch, Clin Trials Off, Changsha, Hunan, Peoples R China.

语种：

英文

期刊：

PLOS ONE

ISSN：

1932-6203

年：

2025

卷：

期：

页码：

e0329272

DOI：

10.1371/journal.pone.0329272

基金类别：

National Natural Science Foundation of China [82203349]; Natural Science Foundation of Hunan Province [2025JJ80111]; Science and Technology Program Foundation of Changsha [kq2403169]; Scientific Research Funds of Health Commission of Changsha [KJ-B2023030]; Scientific Research Project of Changsha Central Hospital [YNKY202201]

机构署名：

本校为第一且通讯机构

院系归属：

医学院

摘要：

3-Methyladenine (3-MA) is widely recognized as a PI3K inhibitor involved in autophagy regulation. However, it is also a byproduct of DNA damage repair, and its role in modulating DNA damage response (DDR) mechanisms remains largely unexplored. Cisplatin (CDDP), a cornerstone chemotherapeutic agent for nasopharyngeal carcinoma (NPC), exerts its cytotoxic effects by inducing DNA damage in tumor cells. This study investigates the combined effects of CDDP and 3-MA on NPC cells. Cell viability and the half-maximal inhibitory concentration (IC50) wer...

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Premature termination of DNA Damage Repair by 3-Methyladenine potentiates cisplatin cytotoxicity in nasopharyngeal carcinoma cells

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