Chlamydia psittaci Induces Autophagy in Human Bronchial Epithelial Cells via PERK and IRE1a, but Not ATF6 Pathway

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成果类型：

期刊论文

作者：

Chen, Li;Huang, Qiaoling;Bai, Qinqin;Tong, Ting;Zhou, You;...

通讯作者：

Chen, LL

作者机构：

[Bai, Qinqin; Xiao, Cui; Chen, Lili; Zhou, You; Chen, Li; Huang, Qiaoling; Tong, Ting] Univ South China, Sch Publ Hlth, Hengyang Med Sch, Dept Publ Hlth Lab Sci, Hengyang, Hunan, Peoples R China.

[Bai, Qinqin; Xiao, Cui; Chen, Lili; Zhou, You; Chen, Li; Huang, Qiaoling; Tong, Ting] Univ South China, Sch Publ Hlth, Hengyang Med Sch, Hunan Key Lab Typ Environm Pollut & Hlth Hazards, Hengyang, Hunan, Peoples R China.

[Bai, Qinqin; Xiao, Cui; Chen, Lili; Zhou, You; Chen, Li; Huang, Qiaoling; Tong, Ting] Hengyang Engn Technol Res Ctr, Hengyang, Hunan, Peoples R China.

[Li, Zhongyu] Univ South China, Hengyang Med Sch, Inst Pathogen Biol, Hengyang, Hunan, Peoples R China.

[Chen, Li] Kweichou Moutai Hosp, Dept Lab Med, Zunyi, Guizhou, Peoples R China.

通讯机构：

[Chen, LL ] U

Univ South China, Sch Publ Hlth, Hengyang Med Sch, Dept Publ Hlth Lab Sci, Hengyang, Hunan, Peoples R China.

Univ South China, Sch Publ Hlth, Hengyang Med Sch, Hunan Key Lab Typ Environm Pollut & Hlth Hazards, Hengyang, Hunan, Peoples R China.

Hengyang Engn Technol Res Ctr, Hengyang, Hunan, Peoples R China.

语种：

英文

关键词：

ATF6;Chlamydia psittaci;IRE1α;PERK;autophagy;unfolded protein reaction

期刊：

Infection and Immunity

ISSN：

0019-9567

年：

2022

卷：

期：

页码：

e0007922

DOI：

10.1128/iai.00079-22

基金类别：

Natural Science Foundation of Hunan ProvinceNatural Science Foundation of Hunan Province [2020JJ4527, 2019JJ50494]; Scientific Research Fund of Hunan Provincial Education DepartmentHunan Provincial Education Department [20A438]; Fund of Hunan Key Laboratory [2019TP1027]

机构署名：

本校为第一且通讯机构

院系归属：

医学院

公共卫生学院

摘要：

Chlamydia psittaci is an important pathogen that causes chronic and atypical pneumonia in humans. Autophagy and the unfolded protein response (UPR) are important mechanisms for regulating the growth of infectious parasitic pathogens in living cells. Here, we explored whether C. psittaci infection induced autophagy via the UPR and the effect of these cellular responses on the survival and replication of C. psittaci in human bronchial epithelial cells (HBEs). Not only were the numbers of autophagosomes and the expression of LC3-II and Beclin1 inc...

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Chlamydia psittaci Induces Autophagy in Human Bronchial Epithelial Cells via PERK and IRE1a, but Not ATF6 Pathway

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