期刊论文

Jiang, Zhisheng;Chang, Lin

英文

Frontiers in Physiology

1664-042X

2017

8

DEC

1032

10.3389/fphys.2017.01032

NIHUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USA [HL122664-01, HL088391]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81670429]; NATIONAL HEART, LUNG, AND BLOOD INSTITUTEUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) - USANIH National Heart Lung & Blood Institute (NHLBI) [R01HL088391, R01HL122664, R01HL122664, R01HL122664, R01HL088391, R01HL088391, R01HL122664, R01HL088391, R01HL088391, R01HL122664] Funding Source: NIH RePORTER

本校为第一且通讯机构

Background: Perivascular adipose tissue (PVAT), which surrounds most vessels, is de facto a distinct functional vascular layer actively contributing to vascular function and dysfunction. PVAT contributes to aortic remodeling by producing and releasing a large number of undetermined or less characterized factors that could target endothelial cells and vascular smooth muscle cells, and herein contribute to the maintenance of vessel homeostasis. Loss of PVAT in mice enhances atherosclerosis, but a causal relationship between PVAT and atheroscleros...