Apolipoprotein A-1 binding protein inhibits inflammatory signaling pathways by binding to apolipoprotein A-1 in THP-1 macrophages

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Zhang, Min;Zhao, Guo-Jun;Yin, Kai;Xia, Xiao-Dan;Gong, Duo;...

通讯作者：

Tang, Chao-Ke;Tang, Xiao-Er

作者机构：

[Gong, Duo; Tang, Chao-Ke; Zhao, Zhen-Wang; Yin, Kai; Chen, Ling-Yan; Xia, Xiao-Dan; Zhang, Min] Univ South China, Hunan Prov Cooperat Innovat Ctr Mol Target New Dr, Key Lab Atherosclerol Hunan Prov, Inst Cardiovasc Dis,Med Res Ctr, Hengyang, Hunan, Peoples R China.

[Zhao, Guo-Jun] Guilin Med Univ, Dept Histol & Embryol, Guilin, Guangxi, Peoples R China.

[Zheng, Xi-Long] Univ Calgary, Hlth Sci Ctr, Dept Biochem & Mol Biol, Libin Cardiovasc Inst Alberta, Calgary, AB, Canada.

[Zheng, Xi-Long] Guangzhou Med Univ, Sch Pharmaceut Sci, Key Lab Mol Targets & Clin Pharmacol, Guangzhou, Guangdong, Peoples R China.

[Tang, Xiao-Er] Shaoyang Univ, Dept Pathophysiol, Shaoyang, Hunan, Peoples R China.

通讯机构：

[Tang, Chao-Ke] U

[Tang, Xiao-Er] S

Univ South China, Inst Cardiovasc Res, Hengyang 421001, Hunan, Peoples R China.

Shaoyang Univ, Coll Med, Dept Pathophysiol, Shaoyang 422000, Hunan, Peoples R China.

语种：

英文

关键词：

Apolipoprotein A-1 (apoA-1);Apolipoprotein A-1 binding protein (AIBP);ATP-binding cassette transporter A1 (ABCA1);Atherosclerosis;Inflammation

期刊：

Circulation Journal

ISSN：

1346-9843

年：

2018

卷：

期：

页码：

1396-1404

DOI：

10.1253/circj.CJ-17-0877

基金类别：

National Natural Sciences Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81570408, 81770461]; University of South China Innovation Foundation for Postgraduates [2016XCX04]; Natural Science Foundation of Hunan ProvinceNatural Science Foundation of Hunan Province [2018JJ3451]

机构署名：

本校为第一且通讯机构

院系归属：

医学院

药学与生物科学学院

摘要：

Background: It has previously been demonstrated that apolipoprotein A-1 (apoA-1) binding protein (AIBP) promotes apoA-1 binding to ATP-binding cassette transporter A1 (ABCA1) and prevents ABCA1 protein degradation so as to inhibit foam cell formation. Because apoA-1 inhibits inflammatory signaling pathways, whether AIBP has an inhibitory effect on inflammatory signaling pathways in THP-1-derived macrophages is investigated. Methods and Results: Analysis of inflammation-related gene expression indicated that AIBP decreased lipopolysaccharide (LP...

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Apolipoprotein A-1 binding protein inhibits inflammatory signaling pathways by binding to apolipoprotein A-1 in THP-1 macrophages

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