Apolipoprotein A-1 binding protein promotes macrophage cholesterol efflux by facilitating apolipoprotein A-1 binding to ABCA1 and preventing ABCA1 degradation

首页 > 成果 > 详情

认领

导出

下载 Link by DOI

反馈

作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Zhang, Min;Li, Liang;Xie, Wei;Wu, Jian-Feng;Yao, Feng;...

通讯作者：

Tang, Chao-Ke

作者机构：

[Gong, Duo; Cheng, Hai-Peng; Liu, Xiao-Yan; Lan, Gang; Xia, Xiao-Dan; Zhang, Min; Liu, Dan; Tang, Chao-Ke; Tan, Yu-Lin; Zhao, Zhen-Wang; Li, Liang; Xie, Wei; Yao, Feng; Zeng, Meng-Ya; Huang, Chong] Univ South China, Inst Cardiovasc Res, Key Lab Atherosclerol Hunan Prov, Med Res Ctr,Hunan Prov Cooperat Innovat Ctr Mol T, Hengyang 421001, Hunan, Peoples R China.

[Wu, Jian-Feng] Univ South China, Affiliated Hosp 2, Dept Cardiovasc Med, Hengyang 421001, Hunan, Peoples R China.

[Zheng, Xi-Long] Univ Calgary, Libin Cardiovasc Inst Alberta, Dept Biochem & Mol Biol, Hlth Sci Ctr, 3330 Hosp Dr NW, Calgary, AB T2N 4N1, Canada.

通讯机构：

[Tang, Chao-Ke] U

Univ South China, Inst Cardiovasc Res, Key Lab Atherosclerol Hunan Prov, Med Res Ctr,Hunan Prov Cooperat Innovat Ctr Mol T, Hengyang 421001, Hunan, Peoples R China.

语种：

英文

关键词：

ABCA1;AIBP;ApoA-1;Atherosclerosis;CSN2;Cholesterol efflux;Foam cell;Ubiquitination

期刊：

Ateroskleroz

ISSN：

2078-256X

年：

2016

卷：

248

页码：

149-159

DOI：

10.1016/j.atherosclerosis.2016.03.008

基金类别：

National Natural Sciences Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81570408, 81300158, 81370377, 81170278, 81300224]; Aid Program for Science and Technology Department of Human Province [2015JC3083]; construct program of the key discipline in Hunan province; Zhengxiang Scholar Program of University of South China [2014-004]

机构署名：

本校为第一且通讯机构

院系归属：

医学院

药学与生物科学学院

摘要：

Rationale: Previous studies have shown that apolipoprotein-1 (apoA-1) binding protein (AIBP) is highly associated with the regulation of apoA-1 metabolism, suggesting its role in the treatment of atherosclerosis. However, how AIBP regulates foam cell formation remains largely unexplored. Objective: To investigate the mechanisms underlying AIBP inhibition of foam cell formation from macrophages. Methods and results: THP-1-derived macrophages were incubated without or with apoA-1 and AIBP, followed by assessing the formation of foam cells and the potential mechanisms. Our results showed that AIB...

反馈

产权有误：本人成果被他人认领

数据有误：数据基本信息有误

归属有误：成果的院系归属、机构署名归属有误

其他原因：

验证码：

看不清楚，换一个

确定

取消

成果认领

标题：

用户	作者	通讯作者	--
	请选择	请选择	--

确定

取消

Apolipoprotein A-1 binding protein promotes macrophage cholesterol efflux by facilitating apolipoprotein A-1 binding to ABCA1 and preventing ABCA1 degradation

反馈

成果认领

提示

该栏目需要登录且有访问权限才可以访问