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PRMT2β, a C-terminal splice variant of PRMT2, inhibits the growth of breast cancer cells

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成果类型:
期刊论文
作者:
Zhong, Jing;Chen, Ya-Jun;Chen, Ling;Shen, Ying-Ying;Zhang, Qing-Hai;...
通讯作者:
Zu, Xu-Yu;Wen, Ge-Bo
作者机构:
[Shen, Ying-Ying; Zhong, Jing; Wen, Ge-Bo; Zu, Xu-Yu; Wen, GB; Zhang, Qing-Hai; Cao, Ren-Xian; Chen, Ling; Chen, Ya-Jun] Univ South China, Affiliated Hosp 1, Inst Clin Med, 69 Chuanshan Rd, Hengyang 421001, Hunan, Peoples R China.
[Chen, Ya-Jun] Univ South China, Affiliated Hosp 2, Dept Metab & Endocrinol, Hengyang 421001, Hunan, Peoples R China.
[Wen, Ge-Bo; Yang, Jing; Cao, Ren-Xian] Univ South China, Affiliated Hosp 1, Dept Metab & Endocrinol, Hengyang 421001, Hunan, Peoples R China.
通讯机构:
[Zu, XY; Wen, GB] U
Univ South China, Affiliated Hosp 1, Inst Clin Med, 69 Chuanshan Rd, Hengyang 421001, Hunan, Peoples R China.
语种:
英文
关键词:
androgen receptor;cyclin D1;epidermal growth factor receptor 2;estrogen receptor;glycogen synthase kinase 3beta;Ki 67 antigen;progesterone receptor;protein arginine methyltransferase;protein arginine methyltransferase 2 beta;protein kinase B;protein p53;transcription factor AP 1;unclassified drug;CCND1 protein, human;cyclin D1;epidermal growth factor receptor 2;ERBB2 protein, human;isoprotein;PRMT2 protein, human;protein arginine methyltransferase;signal peptide;tumor marker;apoptosis;Article;breast cancer;breast carcinogenesis;carboxy terminal sequence;CCND1 gene;cell count;cell proliferation;colony formation;controlled study;disease association;G1 phase cell cycle checkpoint;gene function;human;human cell;human tissue;immunoreactivity;MCF-7 cell line;priority journal;protein expression;S phase cell cycle checkpoint;signal transduction;tissue microarray;transcription initiation;transcription regulation;alternative RNA splicing;breast tumor;case control study;cell proliferation;female;gene expression regulation;genetics;metabolism;pathology;prognosis;tumor cell culture;Alternative Splicing;Apoptosis;Biomarkers, Tumor;Breast Neoplasms;Case-Control Studies;Cell Proliferation;Cyclin D1;Female;Gene Expression Regulation, Neoplastic;Humans;Intracellular Signaling Peptides and Proteins;Prognosis;Protein Isoforms;Protein-Arginine N-Methyltransferases;Receptor, ErbB-2;Tumor Cells, Cultured
期刊:
ONCOLOGY REPORTS
ISSN:
1021-335X
年:
2017
卷:
38
期:
2
页码:
1303-1311
基金类别:
The present study was supported by projects from the National Natural Science Foundation of China (grant nos. 31200573, 81272355 and 81472608), the Key Project of the Education Department of Hunan Province (16A189), the Natural Science Foundation of Hunan Province (2016JJ4077) and the Young Talents Program of the University of South China.
机构署名:
本校为第一且通讯机构
院系归属:
医学院
摘要:
Our previous study reported several alternative splicing variants of arginine N-methyltransferase 2 (PRMT2), which lose different exons in the C-terminals of the wild-type PRMT2 gene. Particularly, due to frame-shifting, PRMT2β encodes a novel amino acid sequence at the C-terminus of the protein, the function of which is not understood. In the present study, we determined the role of PRMT2β in breast cancer cell proliferation, apoptosis and its effect on the Akt signaling pathway. Stable breast cancer MCF7 cell line with lentivirus-mediated P...

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