PRMT2 beta, a C-terminal splice variant of PRMT2, inhibits the growth of breast cancer cells

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成果类型：

期刊论文

作者：

Zhong, Jing;Chen, Ya-Jun;Chen, Ling;Shen, Ying-Ying;Zhang, Qing-Hai;...

通讯作者：

Zu, Xu-Yu;Wen, Ge-Bo

作者机构：

[Shen, Ying-Ying; Zhong, Jing; Wen, Ge-Bo; Zu, Xu-Yu; Wen, GB; Zhang, Qing-Hai; Cao, Ren-Xian; Chen, Ling; Chen, Ya-Jun] Univ South China, Affiliated Hosp 1, Inst Clin Med, 69 Chuanshan Rd, Hengyang 421001, Hunan, Peoples R China.

[Chen, Ya-Jun] Univ South China, Affiliated Hosp 2, Dept Metab & Endocrinol, Hengyang 421001, Hunan, Peoples R China.

[Wen, Ge-Bo; Yang, Jing; Cao, Ren-Xian] Univ South China, Affiliated Hosp 1, Dept Metab & Endocrinol, Hengyang 421001, Hunan, Peoples R China.

通讯机构：

[Zu, XY; Wen, GB] U

Univ South China, Affiliated Hosp 1, Inst Clin Med, 69 Chuanshan Rd, Hengyang 421001, Hunan, Peoples R China.

语种：

英文

关键词：

PRMT2 beta;antitumor;proliferation;breast cancer

期刊：

ONCOLOGY REPORTS

ISSN：

1021-335X

年：

2017

卷：

期：

页码：

1303-1311

DOI：

10.3892/or.2017.5786

基金类别：

National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [31200573, 81272355, 81472608]; Education Department of Hunan Province [16A189]; Natural Science Foundation of Hunan ProvinceNatural Science Foundation of Hunan Province [2016JJ4077]; University of South China

机构署名：

本校为第一且通讯机构

院系归属：

医学院

摘要：

Our previous study reported several alternative splicing variants of arginine N-methyltransferase 2 (PRMT2), which lose different exons in the C-terminals of the wild-type PRMT2 gene. Particularly, due to frame-shifting, PRMT2 beta encodes a novel amino acid sequence at the C-terminus of the protein, the function of which is not understood. In the present study, we determined the role of PRMT2 beta in breast cancer cell proliferation, apoptosis and its effect on the Akt signaling pathway. Stable breast cancer MCF7 cell line with lentivirus-mediated PRMT2 beta overexpression was obtained after ...

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PRMT2 beta, a C-terminal splice variant of PRMT2, inhibits the growth of breast cancer cells

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