Effect of c-fos gene silence on PM2.5-induced miRNA alteration in human bronchial epithelial cells

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成果类型：

期刊论文

作者：

Cai, Ying;Li, Runbing;Zheng, Kai;Wang, Bingyu;Qin, Shuangjian;...

通讯作者：

Zhang, Z.

作者机构：

[Zhang, Zhaohui; Cai, Ying; Li, Runbing; Wang, Bingyu; Zheng, Kai] Univ South China, Sch Publ Hlth, Hengyang 421001, Hunan, Peoples R China.

[Xu, Xinyun; Cai, Ying; Qin, Shuangjian; Li, Runbing; Wang, Bingyu; Zheng, Kai; Li, Boru; Huang, Haiyan] Shenzhen Ctr Dis Control & Prevent, Inst Environm & Hlth, Shenzhen 518055, Guangdong, Peoples R China.

[Qin, Shuangjian; Li, Boru] Cent South Univ, Xiangya Sch Publ Hlth, Changsha 410078, Hunan, Peoples R China.

通讯机构：

[Zhang, Z.] S

School of Public Health, China

语种：

英文

关键词：

PM2;c-fos gene;Gene silence;miRNA;Bioinformatics

期刊：

Environmental Toxicology and Pharmacology

ISSN：

1382-6689

年：

2021

卷：

页码：

103607

DOI：

10.1016/j.etap.2021.103607

基金类别：

Shenzhen Science and Technology Innovation Committee, China [JCYJ20190807102205480, 20190801152345759]; Natural Science Foundation of Guangdong ProvinceNational Natural Science Foundation of Guangdong Province [2019A1515011080]

机构署名：

本校为第一机构

院系归属：

公共卫生学院

摘要：

Human bronchial epithelial (HBE) cells and c-fos-silenced HBE cells were first exposed to fine particulate matter (PM2.5) and the resulting miRNA sequenced. Thereafter, a weighted gene co-expression network analysis was performed using Cytoscape software to visualize the interactions between identified hub miRNAs and their target genes. Nine differentially expressed miRNAs in hub miRNAs were identified in the different treatment groups, of which miR-25-3p, miR-215-5p, and miR-145-5p were selected for further study. Following qPCR validation, both miR-25-3p and miR-215-5p were found to be signi...

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Effect of c-fos gene silence on PM2.5-induced miRNA alteration in human bronchial epithelial cells

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