Treponema pallidum flagellins stimulate MMP-9 and MMP-13 expression via TLR5 and MAPK/NF-κB signaling pathways in human epidermal keratinocytes

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Jiang, Chuanhao;Xu, Man;Kuang, Xingxing;Xiao, Jinhong;Tan, Manyi;...

通讯作者：

Wu, Yimou

作者机构：

[Jiang, Chuanhao; Wu, Yimou; Zhao, Feijun; Tan, Manyi; Xie, Yafeng; Kuang, Xingxing; Xu, Man; Xiao, Yongjian] Univ South China, Hunan Prov Key Lab Special Pathogens Prevent & Co, Med Coll,Inst Pathogen Biol, Hunan Prov Cooperat Innovat Ctr Mol Target New Dr, Hengyang 421001, Peoples R China.

[Jiang, Chuanhao] Cent S Univ, Xiangya Hosp 2, Dept Lab Med, Changsha 410011, Hunan, Peoples R China.

[Xiao, Jinhong] Hunan Prov Peoples Hosp, Clin Lab, Changsha 410005, Hunan, Peoples R China.

通讯机构：

[Wu, Yimou] U

Univ South China, Hunan Prov Key Lab Special Pathogens Prevent & Co, Med Coll,Inst Pathogen Biol, Hunan Prov Cooperat Innovat Ctr Mol Target New Dr, Hengyang 421001, Peoples R China.

语种：

英文

关键词：

*Flagellin;*Keratinocytes;*Matrix metalloproteinase;*Syphilis;*Treponema pallidum

期刊：

Experimental Cell Research

ISSN：

0014-4827

年：

2017

卷：

361

期：

页码：

46-55

DOI：

10.1016/j.yexcr.2017.09.040

基金类别：

This work was supported by the National Natural Science Foundation of China (Grant No. 81471576 and 81701577 ), Hunan Provincial Key Laboratory for Special Pathogens Prevention and Control Foundation (Grant No. 2014-5 ), and the Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study (Grant No. 2015-351 ).

机构署名：

本校为第一且通讯机构

院系归属：

医学院

药学与生物科学学院

摘要：

Syphilis is a chronic disease caused by Treponema pallidum and the pathogenesis is still unclear. T. pallidum infection induced inflammatory responses are involved in the immunopathological damage in skin and other tissues. Flagellin, the monomeric subunit of bacterial flagella, is a classic pathogen associated molecular patterns (PAMPs) that interacts to TLR5 and induces inflammatory responses. Keratinocytes, as immune sentinels recognize the PAMPs via TLRs, play an important role in skin innate immune response. Matrix metalloproteinases (MMPs...

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Treponema pallidum flagellins stimulate MMP-9 and MMP-13 expression via TLR5 and MAPK/NF-κB signaling pathways in human epidermal keratinocytes

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