Treponema pallidum flagellin FlaA2 induces IL-6 secretion in THP-1 cells via the Toll-like receptor 2 signaling pathway

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成果类型：

期刊论文

作者：

Xie, Yafeng;Xu, Man;Xiao, Yongjian;Liu, Zhuoran;Jiang, Chuanhao;...

通讯作者：

Yimou Wu

作者机构：

[Wu, Yimou; Zhao, Feijun; Kuang, Xingxing; Xu, Man; Zeng, Tiebing; Jiang, Chuanhao; Xie, Yafeng; Liu, Zhuoran; Wang, Chuan; Xiao, Yongjian] Univ South China, Hunan Prov Key Lab Special Pathogens Prevent & Co, Inst Pathogen Biol,Med Coll, Hengyang 421001, Peoples R China.

[Wang, Yu; Liu, Huaming; Peng, Jing; Li, Chun; Liu, Bin; Xie, Yafeng; Liu, Zhuoran; Zhang, Xiaotuan; Xiao, Yongjian; Wu, Haiying] Univ South China, Affiliated Hosp 2, Dept Clin Lab, Hengyang 421001, Peoples R China.

[Liu, Shuangquan] Univ South China, Affiliated Hosp 1, Dept Clin Lab, Hengyang 421001, Peoples R China.

通讯机构：

[Yimou Wu] I

Institution of Pathogenic Biology, Medical College, University of South China, Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study, University of South China, Hunan Provincial Key Laboratory for Special Pathogens Prevention and Control, University of South China, Hengyang 421001, China

语种：

英文

关键词：

*Flagellin FlaA2;*Human monocytic cells;*IL-6;*Inflammation;*TLR2 signaling;*Treponema pallidum

期刊：

Molecular Immunology

ISSN：

0161-5890

年：

2017

卷：

期：

页码：

42-51

DOI：

10.1016/j.molimm.2016.11.005

基金类别：

National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81471576, 81273322, 81373230]; Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study [2015-351]; Hunan Provincial Key Laboratory for Special Pathogens Prevention and Control Foundation [2014-5]

机构署名：

本校为第一机构

院系归属：

医学院

摘要：

Treponema pallidum subsp. pallidum membrane proteins are considered as potent inducers in the initiation and development of inflammation. In the present study, the mechanism that leads to the production of interleukin 6 (IL-6), one of the key proinflammatory cytokines, by human monocytic THP-1 cells when these cells are treated with T. pallidum flagellin FlaA2 was investigated. Stimulation with flagellin FlaA2 can induce IL-6 expression in human monocytes and augment the phosphorylation of ERK, p38, and NF-κB, but has no effect on the phosphor...

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Treponema pallidum flagellin FlaA2 induces IL-6 secretion in THP-1 cells via the Toll-like receptor 2 signaling pathway

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