Important Role of TNF-alpha in Inhibitory Effects of Radix Sophorae Flavescentis Extract on Vascular Restenosis in a Rat Carotid Model of Balloon Dilatation Injury
Ministry of Science and Technology of China [2004DFA06400]; Chongqing Municipal Government of China [CSTC-2006AA 5014-3, DRC2005-1006]
机构署名：
本校为第一机构
院系归属：
医学院
摘要：
The aim of this study was to determine the molecular mechanism underlying the inhibition of vascular restenosis by Radix Sophorae Flavescentis (RSF) extract after balloon dilatation injury. In a rat carotid model of balloon dilatation injury, the RSF extract showed a significant inhibitory effect on vascular restenosis. Immunohistochemistry showed that the expression of tumor necrosis factor-α(TNF-α) in the vascular focus was markedly reduced upon treatment with the RSF extract, whereas the expression of proliferating cell nuclear antigens (P...
