Genistein Protects H9c2 Cardiomyocytes against Chemical Hypoxia-Induced Injury via Inhibition of Apoptosis.

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Shi, Ya-Ning;Zhang, Xiu-Qin;Hu, Zhe-Yu;Zhang, Chan-Juan;Liao, Duan-Fang;...

通讯作者：

Qin, L;Huang, HL

作者机构：

[Qin, Li; Shi, Ya-Ning; Zhang, Chan-Juan; Liao, Duan-Fang] Hunan Univ Chinese Med, Sch Pharm, 300 Xueshi Rd, Changsha 410208, Hunan, Peoples R China.

[Shi, Ya-Ning; Zhang, Chan-Juan; Liao, Duan-Fang; Qin, Li] Hunan Univ Chinese Med, Div Stem Cell Regulat & Applicat, Changsha, Hunan, Peoples R China.

[Huang, HL; Huang, Hong-Lin; Zhang, Xiu-Qin] Univ South China, Dept Pharmacol, 28 Changsheng West Rd, Hengyang 421001, Hunan, Peoples R China.

[Hu, Zhe-Yu] Cent S Univ, Hunan Canc Hosp, Changsha, Hunan, Peoples R China.

[Hu, Zhe-Yu] Cent S Univ, Affiliated Canc Hosp, Xiangya Med Sch, Changsha, Hunan, Peoples R China.

通讯机构：

[Qin, L ] H

[Huang, HL ] U

Hunan Univ Chinese Med, Sch Pharm, 300 Xueshi Rd, Changsha 410208, Hunan, Peoples R China.

Univ South China, Dept Pharmacol, 28 Changsheng West Rd, Hengyang 421001, Hunan, Peoples R China.

语种：

英文

关键词：

caspase 3;cobalt chloride;genistein;hypoxia inducible factor 1alpha;Notch1 receptor;protein Bax;protein bcl 2;cardiotonic agent;cobalt;genistein;animal cell;apoptosis;Article;cardiac muscle cell;cell damage;cell protection;cell viability;controlled study;heart protection;hypoxia;nonhuman;priority journal;protein expression;rat;upregulation;animal;apoptosis;cardiac muscle cell;cell hypoxia;cell proliferation;cell survival;drug effect;mitochondrion;pathology;Western blotting;Animals;Apoptosis;Blotting, Western;Cardiotonic Agents;Cell Hypoxia;Cell Proliferation;Cell Survival;Cobalt;Genistein;Mitochondria;Myocytes, Cardiac;Rats;Up-Regulation

期刊：

PHARMACOLOGY

ISSN：

0031-7012

年：

2019

卷：

103

期：

5-6

页码：

282-290

DOI：

10.1159/000497061

基金类别：

The authors gratefully acknowledge the financial support from the National Natural Sciences Foundation of China (No. 81270359 and No. 81774130 to L.Q.; no. 81670268 to D.-F.L.); Key Projectsof Hunan Traditional Chinese Medicine Administration (no. 201614 to L.Q.); Science Foundation for Distinguished Young Scholars of Hunan Province (no. 2018JJ1018 to L.Q.); the Natural Science Foundation of Guangdong (no. 2016A030313026 to D.- F.L.), and Hunan Provincial Key Discipline of Pharmaceutical The authors gratefully acknowledge the financial support from the National Natural Sciences Foundation of China (No. 81270359 and No. 81774130 to L.Q.; no. 81670268 to D.-F.L.); Key Projects of Hunan Traditional Chinese Medicine Administration (no. 201614 to L.Q.); Science Foundation for Distinguished Young Scholars of Hunan Province (no. 2018JJ1018 to L.Q.); the Natural Science Foundation of Guangdong (no. 2016A030313026 to D.-F.L.), and Hunan Provincial Key Discipline of Pharmaceutical Science.

机构署名：

本校为通讯机构

院系归属：

药学与生物科学学院

摘要：

BACKGROUND/AIMS: Hypoxia can induce cell injury in cardiomyocytes and further lead to cardiovascular diseases. Genistein (Gen), the predominant isoflavone found in soy products, has shown protective effects on cardiovascular system. The aim of the present study was to investigate the cardioprotective effect of Gen against chemical hypoxia-induced injury. METHODS: Cobalt chloride (CoCl2) was administrated to trigger chemical hypoxia in H9c2 cardiomyocytes. Cell proliferation was detected by using MTT assay. The expression level of hypoxia-related proteins (hypoxia-inducible factor [HIF]-1alpha ...

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Genistein Protects H9c2 Cardiomyocytes against Chemical Hypoxia-Induced Injury via Inhibition of Apoptosis.

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