Microneedle-Loaded Gene-Editable Nanohybrids Engineer Cancer Cells by Telomere Stress Induction and Metabolic Interference for Enhanced Cuproptosis and Immunotherapy

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成果类型：

期刊论文

作者：

Luan, Xiaowei;Du, Shiyu;Liu, Zhiyong;He, Bangshun*;Pan, Yongchun;...

通讯作者：

He, Bangshun;Kong, Desheng;Song, YJ;He, BS;Han, X

作者机构：

[Kong, Desheng; Pan, Yongchun; He, Bangshun; Luan, Xiaowei; Du, Shiyu; Liu, Zhiyong; Li, Yanyan; Song, Yujun] Nanjing Univ, Coll Engn & Appl Sci, State Key Lab Analyt Chem Life Sci, Nanjing 210023, Peoples R China.

[He, Bangshun] Nanjing Med Univ, Nanjing Hosp 1, Dept Lab Med, Nanjing 210006, Peoples R China.

[Han, Xin] Nanjing Univ Chinese Med, Jiangsu Collaborat Innovat Ctr Chinese Med Resourc, Sch Med & Holist Integrat Med, Nanjing 210023, Peoples R China.

[Yang, Jian] Univ South China, Sch Elect Engn, Dept Biomed Engn, Hengyang 421002, Peoples R China.

通讯机构：

[Kong, DS; He, BS; Song, YJ ; Han, X ; He, BS ] N

Nanjing Univ, Coll Engn & Appl Sci, State Key Lab Analyt Chem Life Sci, Nanjing 210023, Peoples R China.

Nanjing Med Univ, Nanjing Hosp 1, Dept Lab Med, Nanjing 210006, Peoples R China.

Nanjing Univ Chinese Med, Jiangsu Collaborat Innovat Ctr Chinese Med Resourc, Sch Med & Holist Integrat Med, Nanjing 210023, Peoples R China.

语种：

英文

关键词：

CRISPR/Cas9;cuproptosis;immunotherapy;metabolic interference;microneedle patch;telomere stress;treatment resistance

期刊：

Advanced Functional Materials

ISSN：

1616-301X

年：

2025

卷：

期：

页码：

2416285-

DOI：

10.1002/adfm.202416285

基金类别：

National Natural Science Foundation of China; National Key R&D Program of China [2019YFA0709200]; Fundamental Research Funds for the Central Universities [2024300315]; Jiangsu Provincial Medical Key Discipline Cultivation Unit [JSDW202239]; Key Research and Development Program of Jiangsu Province [BE2021373]; State Key Laboratory of Analytical Chemistry for Life Science [5431ZZXM2304]; Program for Innovative Talents and Entrepreneur in Jiangsu (China); Postgraduate Research & Practice Innovation Program of Jiangsu Province [KYCX23_0146]; [22477056]; [82472379]; [32471475]

机构署名：

本校为其他机构

院系归属：

电气工程学院

摘要：

Cuproptosis, a novel copper-driven cell death, offers potential for cancer therapy, yet challenges persist in targeted delivery of copper ions and therapeutic resistance management. Here, CuTG-Cas9@PLL, a cuproptosis nano-inducer for efficient delivery of Cu ions, 6-Thio-dG (6-thio-2 '-deoxyguanosine), and CRISPR/Cas9 to enhance cuproptosis and immunotherapy via telomere stress and metabolic interference is developed. This system, combined with microneedle patches for transdermal delivery in melanoma treatment, targets the "Warburg effect," a key resistance mechanism, through CRISPR/Cas9-media...

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Microneedle-Loaded Gene-Editable Nanohybrids Engineer Cancer Cells by Telomere Stress Induction and Metabolic Interference for Enhanced Cuproptosis and Immunotherapy

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