Nucleolin regulates the proliferation of vascular smooth muscle cells in atherosclerotic via Aurora B

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作者信息关键词期刊信息基础信息归属信息摘要

成果类型：

期刊论文

作者：

Sun, Hui;Huang, Lingjin;Liang, Pengfei;Tang, Yuting;Chen, Cheng;...

通讯作者：

Jiang, Bimei

作者机构：

[Xiao, Xianzhong; Luo, Zhengyang; Lin, Xiaofang; Sun, Hui; Chen, Cheng; Jiang, Bimei; Chen, Huan; Tang, Yuting] Cent South Univ, Xiangya Sch Med, Dept Pathophysiol, Sepsis Translat Med Key Lab Hunan Prov, Changsha, Hunan, Peoples R China.

[Sun, Hui] Univ South China, Inst Cardiovasc Dis, Dept Pathophysiol, Hengyang, Hunan, Peoples R China.

[Sun, Hui] Univ South China, Key Lab Arteriosclerol Hunan Prov, Hengyang, Hunan, Peoples R China.

[Huang, Lingjin] Cent South Univ, Dept Cardiothorac Surg, Xiangya Hosp, Changsha, Hunan, Peoples R China.

[Liang, Pengfei] Cent South Univ, Xiangya Hosp, Dept Burns & Plast Surg, Changsha, Hunan, Peoples R China.

通讯机构：

[Jiang, Bimei] C

Cent South Univ, Xiangya Sch Med, Dept Pathophysiol, Sepsis Translat Med Key Lab Hunan Prov, Changsha, Hunan, Peoples R China.

语种：

英文

关键词：

atherosclerosis;Aurora B;cell cycle;nucleolin;vascular smooth muscle cells

期刊：

Journal of Cellular and Molecular Medicine

ISSN：

1582-1838

年：

2021

卷：

期：

页码：

751-762

DOI：

10.1111/jcmm.16125

基金类别：

National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81671895, 81770306, 81871610, 81971820, 81974287]; Province Natural Science Foundation of Hunan [2018JJ2547]

机构署名：

本校为其他机构

院系归属：

医学院

摘要：

Vascular smooth muscle cells (VSMCs) play a significant role in atherosclerosis. As a multifunctional protein, nucleolin (NCL) is involved in many important physiological and pathological processes. In this study, we aimed to investigate the role of nucleolin in VSMCs proliferation and cell cycle. The expression of nucleolin increased in VSMCs of mice with aortas advanced plaques. With the left common carotid-artery ligation-injury model, immunofluorescence staining revealed that nucleolin and Ki67 expression increased in VSMCs in mice left car...

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Nucleolin regulates the proliferation of vascular smooth muscle cells in atherosclerotic via Aurora B

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